4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-YL]-2-pyridylamine

Base Information

Chemical Name:4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-YL]-2-pyridylamine
CAS No.:365428-84-8
Molecular Formula:C₁₆H₁₄FN₃S
Molecular Weight:299.372
Hs Code.:
DSSTox Substance ID:DTXSID70468592
Wikidata:Q82295870

Synonyms:365428-84-8;4-[2-ETHYL-4-(4-FLUOROPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYLAMINE;SCHEMBL2513403;DTXSID70468592;HDIUGMXXGNINFC-UHFFFAOYSA-N;4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine-2-amine

Suppliers and Price of 4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-YL]-2-pyridylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-YL]-2-pyridylamine

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:299.08924679
Heavy Atom Count:21
Complexity:336

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=NC(=C(S1)C2=CC(=NC=C2)N)C3=CC=C(C=C3)F

Technology Process of 4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-YL]-2-pyridylamine

There total 9 articles about 4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-YL]-2-pyridylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1231880-61-7
N-benzyl-4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine-2-amine

: 365428-84-8
4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-amine

Guidance literature:: N-benzyl-4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine-2-amine; With sulfuric acid; at 20 ℃; Ice cooling;

With sodium hydroxide; In water; pH=10; Ice water;

Reference yield: 76.0%

: 2-(2-amino-4-pyridyl)-2-bromo-1-(4-fluorophenyl)ethanone hydrobromide

: 631-58-3
thiopropanamide

: 365428-84-8
4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-amine

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm050165o

Reference yield:

: 325770-31-8
1-(4-fluorobenzoyl)-2-methylaziridine

: 365428-84-8
4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 82 percent / Br₂; AcOH / 3 h / 80 °C

3.1: 76 percent / dimethylformamide / 14 h / 20 °C

With n-butyllithium; bromine; acetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o