(+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate

Base Information

Chemical Name:(+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate
CAS No.:1309655-44-4
Molecular Formula:C₂₅H₃₁F₂NO₃Si
Molecular Weight:459.608
Hs Code.:

Synonyms:(+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate

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Chemical Property of (+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate

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Technology Process of (+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate

There total 3 articles about (+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1309655-38-6
(+/-)-2-(trimethylsilyl)ethyl 1-amino-2,2-difluorocyclohexanecarboxylate

: 14002-51-8
4-biphenyl-carboxylic acid chloride

: 1309655-44-4
(+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201100113

Reference yield:

: 911395-49-8
2-(trimethylsilyl)ethyl 6,6-difluoro-1-[(4-methoxyphenyl)amino]-3-cyclohexene-1-carboxylate

: 1309655-44-4
(+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / 7757.43 Torr / Inert atmosphere

2: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C / Inert atmosphere

3: dmap; triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; ammonium cerium (IV) nitrate; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; water; ethyl acetate; acetonitrile;
DOI:10.1002/chem.201100113

Reference yield:

: C₁₉H₂₉F₂NO₃Si

: 1309655-44-4
(+/-)-2-(trimethylsilyl)ethyl 1-(4-phenylbenzamido)-2,2-difluorocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C / Inert atmosphere

2: dmap; triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; ammonium cerium (IV) nitrate; triethylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1002/chem.201100113