1-CBZ-3-(2-HYDROXY-ETHYL)-PIPERIDINE

Base Information

• Chemical Name: 1-CBZ-3-(2-HYDROXY-ETHYL)-PIPERIDINE
• CAS No.: 115909-93-8
• Molecular Formula: C15H21 N O3
• Molecular Weight: 263.337
• Hs Code.: 2933399090
• Mol file: 115909-93-8.mol

Synonyms:3-(2-HYDROXY-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-CBZ-3-(2-HYDROXY-ETHYL)-PIPERIDINE;(R)-3-(2-HYDROXY-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Chemical Property of 1-CBZ-3-(2-HYDROXY-ETHYL)-PIPERIDINE

Chemical Property:

• Vapor Pressure: 2.06E-07mmHg at 25°C
• Refractive Index: 1.544
• Boiling Point: 408.7°Cat760mmHg
• Flash Point: 201°C
• PSA: 49.77000
• Density: 1.14g/cm³
• LogP: 2.35550

Purity/Quality:

98%min ^*data from raw suppliers

1-Cbz-3-(2-hydroxy-ethyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CBZ-3-(2-HYDROXY-ETHYL)-PIPERIDINE

There total 10 articles about 1-CBZ-3-(2-HYDROXY-ETHYL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C15H19NO2 → (+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-ethanol (115909-93-8)

Guidance literature:

C₁₅H₁₉NO₂; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1246/cl.180147

Reference yield: 80.0%

benzyl chloroformate (501-53-1,94274-21-2) + (+)-(R)-Piperidin-3-ethanol (115909-92-7) → (+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-ethanol (115909-93-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 1.5h;

DOI:10.1002/hlca.19870700802

Reference yield:

3-(2-hydroxyethyl)piperidine (73579-06-3,115909-92-7) → (+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-ethanol (115909-93-8)

Guidance literature:

Multi-step reaction with 2 steps

2: 80 percent / 4N NaOH / tetrahydrofuran; H₂O / 1.5 h / 0 °C

With sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1002/hlca.19870700802

upstream raw materials:

benzyl chloroformate

(+)-(R)-Piperidin-3-ethanol

3-(2-hydroxyethyl)piperidine

3-Piperidinylacetic Acid

Downstream raw materials:

(+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-propionitril

(+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-ethhyl p-Toluolsulfonat

Refernces

• 1、 Brehm, Renate,Ohnhaeuser, Dieter,Gerlach, Hans. "Synthese und Bestimmung des Chiralitaetssinns von (+)-(R)-1-Azabicyclononan-2-on". . p. 1981 - 1987. Retrieved 2007/10/02.