(R)-3-Aminobutyricacidethylester

Base Information

• Chemical Name: (R)-3-Aminobutyricacidethylester
• CAS No.: 115880-49-4
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.175
• Mol file: 115880-49-4.mol

Synonyms:Butanoicacid, 3-amino-, ethyl ester, (R)-

Chemical Property of (R)-3-Aminobutyricacidethylester

Chemical Property:

• Boiling Point: 169℃
• PKA: 8.84±0.10(Predicted)
• Flash Point: 42℃
• PSA: 52.32000
• Density: 0.970
• LogP: 0.98710

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-3-Aminobutyric acid ethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-Aminobutyricacidethylester

There total 44 articles about (R)-3-Aminobutyricacidethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl (S)-(+)-3-azidobutyrate (226910-85-6) → (S)-ethyl 3-aminobutyrate (5303-65-1,22657-48-3,69677-12-9,115880-49-4)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In toluene; at 20 ℃; for 2h; under 15001.5 Torr;

Reference yield: 95.0%

(S)-ethyl 3-(((2S,5S)-1-oxido-2,5-diphenylphospholan-1-yl)amino)butanoate → (S)-ethyl 3-aminobutyrate (5303-65-1,22657-48-3,69677-12-9,115880-49-4)

Guidance literature:

With hydrogenchloride; In ethanol; Reflux;

DOI:10.1055/s-0036-1589080

Reference yield: 89.0%

ethyl (3S)-3-{benzyl[(1S)-1-phenylethyl]amino}butanoate (152673-22-8) → (S)-ethyl 3-aminobutyrate (5303-65-1,22657-48-3,69677-12-9,115880-49-4)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; for 48h; under 3040 Torr; Ambient temperature;

DOI:10.1016/0040-4039(95)01813-W

upstream raw materials:

[9,9']Biphenanthrenyl-10,10'-diol; compound with 3-amino-butyric acid ethyl ester

[9,9']Biphenanthrenyl-10,10'-diol; compound with 3-amino-butyric acid ethyl ester

(2R,4R)-N-benzyl-2-methyl-4-phenyl-1,3-oxazolidine

ethyl bromoacetate

Downstream raw materials:

3-benzylamino-butyric acid methyl ester

(S)-N-benzyl-5-methylpyrrolidin-3-one

3-(4-nitrophenoxycarbonylamino)butyric acid ethyl ester

(S)-ethyl 3-((tert-butoxycarbonyl)amino)butanoate

Refernces

• 1、 Gedey, Szilvia,Liljeblad, Arto,Fueloep, Ferenc,Kanerva, Liisa T.. "Sequential resolution of ethyl 3-aminobutyrate with carboxylic acid esters by Candida antarctica lipase B". . p. 2573 - 2581. Retrieved 1999.
• 2、 Mutti, Francesco G.,Fuchs, Christine S.,Pressnitz, Desiree,Turrini, Nikolaus G.,Sattler, Johann H.,Lerchner, Alexandra,Skerra, Arne,Kroutil, Wolfgang. "Amination of ketones by employing two new (S)-selective ω-transaminases and the his-tagged ω-TA from Vibrio fluvialis". . p. 1003 - 1007. Retrieved 2012.
• 3、 Mutti, Francesco G.,Fuchs, Christine S.,Pressnitz, Desiree,Sattler, Johann H.,Kroutil, Wolfgang. "Stereoselectivity of four (R)-selective transaminases for the asymmetric amination of ketones". . p. 3227 - 3233. Retrieved 2011.
• 4、 Roche, Didier,Prasad, Kapa,Repic, Oljan. "Enantioselective acylation of β-aminoesters using penicillin G acylase in organic solvents". . p. 3665 - 3668. Retrieved 1999.
• 5、 -. "QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS". Paragraph 0619; 0624; 0625. . Retrieved 2016/04/19.