N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide

Base Information

Chemical Name:N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide
CAS No.:119487-27-3
Molecular Formula:C₂₄H₂₂FN₃O₂
Molecular Weight:403.456
Hs Code.:

Synonyms:N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide

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Chemical Property of N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide

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Technology Process of N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide

There total 5 articles about N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 123903-97-9
1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

: 119487-27-3
N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 10h; pH 8;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-37-9
1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-(aminomethyl)-2H-1,4-benzodiazepin-2-one

: 119487-27-3
N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 23 °C / overnight

2: 95 percent / Lawesson's reagent / toluene / 1.5 h / Heating

3: 50 percent / W-2 Raney nickel / ethanol / 50 h

4: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

5: 42 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / CH₂Cl₂ / 10 h / pH 8

With Lawessons reagent; dmap; hydrogen bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; W-2 Raney nickel; In ethanol; dichloromethane; toluene;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-76-6
1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-<<(benzyloxy)carbonyl>methyl>-2H-1,4-benzodiazepin-2-thione

: 119487-27-3
N-[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-2-hydroxy-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / W-2 Raney nickel / ethanol / 50 h

2: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

3: 42 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / CH₂Cl₂ / 10 h / pH 8

With hydrogen bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; W-2 Raney nickel; In ethanol; dichloromethane;
DOI:10.1021/jm00163a069