benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate

Base Information

Chemical Name:benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate
CAS No.:87377-75-1
Molecular Formula:C₂₆H₃₂N₂O₆
Molecular Weight:468.55
Hs Code.:

Synonyms:benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate

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Chemical Property of benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate

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Technology Process of benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate

There total 10 articles about benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 87377-74-0
benzyl 3-(methoxycarbonylmethyl)-4'-(ethoxycarbonylmethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate

: 87377-75-1
benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate

Guidance literature:: With diborane; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)88698-1

Reference yield:

: 74839-03-5
5-ethoxycarbonyl-4-ethoxycarbonylmethyl-2-methylpyrrole-3-carboxylic acid

: 87377-75-1
benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 79 percent / ethanol; H₂O / 5 h / Heating

2: 73 percent / H₂ / Raney Ni / ethanol / 140 °C / 76000.1 Torr

3: sulphuryl chloride / diethyl ether / 72 h / 20 °C

4: NaOAc / dioxane; H₂O / 1.5 h / 70 °C

5: 84 percent / NaHCO₃, I₂, KI / H₂O; methanol / 65 °C

6: 99 percent / NaOEt, H₂ / Adams PtO₂ / methanol / 0.5 h / 20 °C / 760 Torr

7: 53 percent / NaOAc / acetic acid / 4 h / Heating

8: 95 percent / diborane / tetrahydrofuran / 2 h / Ambient temperature

With sulfuryl dichloride; hydrogen; iodine; sodium ethanolate; sodium acetate; sodium hydrogencarbonate; potassium iodide; diborane; platinum(IV) oxide; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water; acetic acid;
DOI:10.1016/S0040-4020(01)88698-1

Reference yield:

: 54278-18-1
ethyl 3-(ethoxycarbonylmethyl)-4,5-dimethylpyrrole-2-carboxylate

: 87377-75-1
benzyl 3,4'-bis-(2-hydroxyethyl)-3',4-dimethyl-5'-ethoxycarbonylpyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sulphuryl chloride / diethyl ether / 72 h / 20 °C

2: NaOAc / dioxane; H₂O / 1.5 h / 70 °C

3: 84 percent / NaHCO₃, I₂, KI / H₂O; methanol / 65 °C

4: 99 percent / NaOEt, H₂ / Adams PtO₂ / methanol / 0.5 h / 20 °C / 760 Torr

5: 53 percent / NaOAc / acetic acid / 4 h / Heating

6: 95 percent / diborane / tetrahydrofuran / 2 h / Ambient temperature

With sulfuryl dichloride; hydrogen; iodine; sodium ethanolate; sodium acetate; sodium hydrogencarbonate; potassium iodide; diborane; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; acetic acid;
DOI:10.1016/S0040-4020(01)88698-1