tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate

Base Information

Chemical Name:tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate
CAS No.:1353891-90-3
Molecular Formula:C₃₀H₃₄Cl₂N₂O₅
Molecular Weight:573.516
Hs Code.:

Synonyms:tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate

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Chemical Property of tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate

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Technology Process of tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate

There total 16 articles about tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1353891-88-9
tert-butyl ((1R,2S)-2-amino-1,2-bis(4-chlorophenyl)ethyl)carbamate

: 2-isopropoxy-4-methoxybenzoic acid

: 1353891-90-3
tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In dichloromethane; at 0 - 20 ℃; for 16h; Product distribution / selectivity;

Reference yield:

: 29559-24-8
4-chlorophenylnitromethane

: 1353891-90-3
tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: H,⁽⁴⁾pyrrolidine(6,7)(MeO)2Quin-BAM / toluene / 24 h / -78 °C

2: sodium tetrahydroborate; methanol / cobalt(II) chloride / 1 h / 0 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 16 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; H,⁽⁴⁾pyrrolidine(6,7)(MeO)2Quin-BAM; cobalt(II) chloride; In dichloromethane; toluene;

Reference yield:

: 622-95-7
4-chlorobenzyl bromide

: 1353891-90-3
tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 3,5-dihydroxyphenol / acetonitrile / 1.17 h / 0 °C

2: H,⁽⁴⁾pyrrolidine(6,7)(MeO)2Quin-BAM / toluene / 24 h / -78 °C

3: sodium tetrahydroborate; methanol / cobalt(II) chloride / 1 h / 0 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 16 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; 3,5-dihydroxyphenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; H,⁽⁴⁾pyrrolidine(6,7)(MeO)2Quin-BAM; cobalt(II) chloride; In dichloromethane; toluene; acetonitrile;