29559-24-8

Basic information

• Product Name: 1-chloro-4-(nitromethyl)benzene
• CAS NO: 29559-24-8
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.581
• Mol File: 29559-24-8.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 263.6°C at 760 mmHg
• Flash Point: 113.2°C
• Density: 1.315g/cm³
• Vapor Pressure: 0.0102mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 1-chloro-4-(nitromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-4-(nitromethyl)benzene(29559-24-8)
• EPA Substance Registry System: 1-chloro-4-(nitromethyl)benzene(29559-24-8)

Safety Data

• Hazardous Substances Data: 29559-24-8(Hazardous Substances Data)

Usage

General Description

1-chloro-4-(nitromethyl)benzene is a chemical compound with the molecular formula C7H6ClNO2. It is a derivative of benzene with a chlorine atom at the 1-position and a nitromethyl group at the 4-position. 1-chloro-4-(nitromethyl)benzene is a pale yellow liquid at room temperature and is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is considered to be moderately toxic and can cause skin and eye irritation upon contact. It is also known to be harmful if ingested or inhaled, and proper safety precautions should be taken when handling this compound.

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 873-76-7 para-Chlorobenzyl alcohol 
• 106-43-4 para-chlorotoluene 
• 140-53-4 p-chlorobenzyl cyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 3848-36-0 4-chlorobenzaldoxime 
• 106-39-8 bromochlorobenzene 
• 75-52-5 nitromethane 
• 622-95-7 4-chlorobenzyl bromide 
• 896-31-1 2-(4-chloro-phenyl)-2-nitro-indan-1,3-dione 
• 17333-85-6 4-chlorophenyldiazonium salt 
• 64-17-5 ethanol 

Downstream Products

• 81798-09-6 [5-(4-Chloro-benzoyl)-2,4-bis-(4-chloro-phenyl)-1H-pyrrol-3-yl]-(4-chloro-phenyl)-methanone 
• 15500-74-0 4-chlorobenzonitrile N-oxide 
• 90346-72-8 2-(4-chloro-phenyl)-2-nitro-propane-1,3-diol 
• 548472-68-0 nutlin-3a 
• 1353891-88-9 tert-butyl ((1R,2S)-2-amino-1,2-bis(4-chlorophenyl)ethyl)carbamate 
• 1353891-92-5 N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide 
• 1353891-90-3 tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate 
• 1353891-93-6 N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide 
• 1353891-52-7 tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate 
• 104-88-1 4-chlorobenzaldehyde 
• 1409943-84-5 C₈H₈ClNO₂ 
• 1409943-84-5 C₈H₈ClNO₂ 
• 1429386-03-7 (S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate 
• 1429386-04-8 (R)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate 

Relevant articles and documents

Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents

5-phenylthiophene derivatives exhibited excellent antifungal activity against Candida albicans, Candida tropicalis and Cryptococcus neoformans. However, optimal compound 7 was inactive against Aspergillus fumigatus and unstable in human liver microsomes in vitro with a half-life of 18.6 min. To discover antifungal agents with a broad spectrum and improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of 4-phenyl-4,5-dihydrooxazole derivatives were designed and synthesized. It was especially encouraging that compound 22a displayed significant antifungal activities against eight susceptible strains and seven FLC-resistant strains. Furthermore, the potent compound 22a could prevent the formation of fungalbiofilms and displayed satisfactory fungicidal activity. In addition, the metabolic stability of compound 22a was improved significantly, with the half-life of 70.5 min. Compound 22a was almost nontoxic to mammalian A549, MCF-7, HepG2, and 293T cells. Moreover, pharmacokinetic studies in SD rats showed that compound 22a exhibited pharmacokinetic properties with a bioavailability of 15.22% and a half-life of 4.44 h, indicating that compound 22a is worthy of further study.

Integrating Hydrogen Production and Transfer Hydrogenation with Selenite Promoted Electrooxidation of α-Nitrotoluenes to E-Nitroethenes

Developing an electrochemical carbon-added reaction with accelerated kinetics to replace the low-value and sluggish oxygen evolution reaction (OER) is markedly significant to pure hydrogen production. Regulating the critical steps to precisely design electrode materials to selectively synthesize targeted compounds is highly desirable. Here, inspired by the surfaced adsorbed SeOx2? promoting OER, NiSe is demonstrated to be an efficient anode enabling α-nitrotoluene electrooxidation to E-nitroethene with up to 99 % E selectivity, 89 % Faradaic efficiency, and the reaction rate of 0.25 mmol cm?2 h?1 via inhibiting side reactions for energy-saving hydrogen generation. The high performance can be associated with its in situ formed NiOOH surface layer and absorbed SeOx2? via Se leaching-oxidation during electrooxidation, and the preferential adsorption of two -NO2 groups of intermediate on NiOOH. A self-coupling of α-carbon radicals and subsequent elimination of a nitrite molecule pathway is proposed. Wide substrate scope, scale-up synthesis of E-nitroethene, and paired productions of E-nitroethene and hydrogen or N-protected aminoarenes over a bifunctional NiSe electrode highlight the promising potential. Gold also displays a similar promoting effect for α-nitrotoluene transformation like SeOx2?, rationalizing the strategy of designing materials to suppress side reactions.

The hydrophobically-tagged MDM2-p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a

We present the first application of hydrophobic tagging to a non-covalent inhibitor of protein-protein interactions. Nutlin-3a-HT, created by fusing the hydrophobic tag HyT13 to the MDM2-p53 interaction inhibitor Nutlin-3a, prevented cellular accumulation of MDM2 upon p53 reactivation, and had a stronger effect on cell viability and the induction of apoptosis than Nutlin-3a.