2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Base Information

Chemical Name:2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride
CAS No.:1620955-46-5
Molecular Formula:C₂₄H₂₃N₅O₂*ClH
Molecular Weight:449.94
Hs Code.:

Synonyms:2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

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Chemical Property of 2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Chemical Property:

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Technology Process of 2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

There total 10 articles about 2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620955-45-4
C₂₉H₃₁N₅O₄

: 1620955-46-5
2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 191338-94-0
ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate

: 1620955-46-5
2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / ethanol / 2 h / Reflux

1.2: 16 h

2.1: methanol; diethyl ether / 1 h / 0 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; toluene / 24 h / Inert atmosphere; Reflux

4.1: hydrazine hydrate / 2 h / 100 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; hydrazine hydrate; cesium fluoride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; toluene;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1620955-46-5
2-(4'-(3-aminopropoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / Inert atmosphere; Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

2.2: 12 h / 65 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; toluene / 24 h / Inert atmosphere; Reflux

4.1: hydrazine hydrate / 2 h / 100 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; caesium carbonate; hydrazine hydrate; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;