2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide

Base Information

• Chemical Name: 2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide
• CAS No.: 638222-87-4
• Molecular Formula: C₂₈H₄₀ClN₃O₇
• Molecular Weight: 566.094

Synonyms:2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide

Chemical Property of 2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide

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Technology Process of 2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide

There total 1 articles about 2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.67%

Chloroacetic anhydride (541-88-8) + 3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl]phenylamine (497969-02-5) → 2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide (638222-87-4)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 20 ℃;

DOI:10.1039/b509230m

Reference yield: 77.0%

2-(4,10-bis-dimethyl-carbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-N,N-dimethyl-acetamide (622872-56-4) + 2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide (638222-87-4) → N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide (869286-17-9)

Guidance literature:

With caesium carbonate; In acetonitrile; at 72 ℃; for 72h;

DOI:10.1039/b509230m

Reference yield: 36.0%

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) + 2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide (638222-87-4) → [4,7-bis-tert-butoxycarbonylmethyl-10-({3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester (869286-21-5)

Guidance literature:

With caesium carbonate; In acetonitrile; at 72 ℃; for 72h;

DOI:10.1039/b509230m

upstream raw materials:

Chloroacetic anhydride

3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl]phenylamine

Downstream raw materials:

[4,7-bis-tert-butoxycarbonylmethyl-10-({3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenylcarbamoyl}methyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester

N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

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