N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

Base Information

Chemical Name:N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide
CAS No.:869286-17-9
Molecular Formula:C₄₈H₈₀N₁₀O₁₀
Molecular Weight:957.224
Hs Code.:

N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

Synonyms:N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

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Chemical Property of N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

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Technology Process of N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

There total 2 articles about N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 622872-56-4
2-(4,10-bis-dimethyl-carbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-N,N-dimethyl-acetamide

: 638222-87-4
2-chloro-N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}acetamide

: 869286-17-9
N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

Guidance literature:: With caesium carbonate; In acetonitrile; at 72 ℃; for 72h;
DOI:10.1039/b509230m

Reference yield:

: 497969-02-5
3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl]phenylamine

: 869286-17-9
N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 61.67 percent / Na₂CO₃ / dioxane / 20 °C

2: 77 percent / Cs₂CO₃ / acetonitrile / 72 h / 72 °C

With sodium carbonate; caesium carbonate; In 1,4-dioxane; acetonitrile;
DOI:10.1039/b509230m

Reference yield: 32.0%

: 109-99-9,24979-97-3,77392-70-2
tetrahydrofuran

: terbium(III) trifluoromethanesulfonate

: 869286-17-9
N-{3-methoxy-4-[16-(2-methoxyphenyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]phenyl}-2-(4,7,10-tris(dimethyl)carbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

: ((C₂H₄NCH₂CON(CH₃)2)3C₂H₄NCH₂CONHC₇H₆ON(C₂H₄O)2C₂H₄N(C₇H₇O)(C₂H₄O)2C₂H₄)Tb(H₂O)⁽³⁺⁾*3O₃SCF₃^(1-)*C₄H₈O=C₅₅H₉₀N₁₀O₂₁F₉S₃Tb

Guidance literature:: In acetonitrile; ligand and Tb compd. (1.1 equiv.) were added to MeCN; soln. was freeze-pump-thawed; stirred under reflux for 24 h under Ar; cooled to room temp.; dropped slowly onto Et2O; decanted; dissolved in CH2Cl2; chromd. (alumina, CH2Cl2/THF, 70/30 to CH2Cl2/THF/MeOH, 60/30/10); elem. anal.;
DOI:10.1039/b509230m