N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide

Base Information

• Chemical Name: N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide
• CAS No.: 1026258-40-1
• Molecular Formula: C₁₄H₁₇N₅O
• Molecular Weight: 271.322
• Mol file: 1026258-40-1.mol

Synonyms:N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide

Chemical Property of N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide

There total 3 articles about N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{4-[(6-Amino-5-nitro-pyridin-2-ylamino)-methyl]-phenyl}-acetamide (91941-10-5) → N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide (1026258-40-1)

Guidance literature:

With hydrogen; nickel; In 1,4-dioxane; at 50 ℃; under 3750.3 Torr;

DOI:10.1021/jm00045a005

Reference yield:

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide (1026258-40-1)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia

2: triethylamine / dioxane

3: H₂ / Raney nickel / dioxane / 50 °C / 3750.3 Torr

With ammonia; hydrogen; triethylamine; nickel; In 1,4-dioxane;

DOI:10.1021/jm00045a005

Reference yield:

2-amino-6-chloro-3-nitropyridine (27048-04-0) → N-{4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-phenyl}-acetamide (1026258-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dioxane

2: H₂ / Raney nickel / dioxane / 50 °C / 3750.3 Torr

With hydrogen; triethylamine; nickel; In 1,4-dioxane;

DOI:10.1021/jm00045a005

upstream raw materials:

N-{4-[(6-Amino-5-nitro-pyridin-2-ylamino)-methyl]-phenyl}-acetamide

2,6-dicholoro-3-nitropyridine

2-amino-6-chloro-3-nitropyridine