Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester
CAS No.:93978-88-2
Molecular Formula:C₁₆H₂₁NO₆S
Molecular Weight:355.412
Hs Code.:

Synonyms:Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester

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Chemical Property of Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester

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Technology Process of Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester

There total 7 articles about Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93960-55-5
methyl 3-O-benzoyl-4-O-benzyl-6-bromo-2,6-dideoxy-α-D-ribo-hexopyranoside

: 93978-88-2
Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) AgF, 2) H₂ / 2) 10percent Pd/C / 1) pyridine, 40 h, 2) CH₃OH-CH₃CO₂H, overnight

2: 62.2 percent / CF₃CO₂H / CH₂Cl₂; cyclohexane / 72 h / Ambient temperature

3: 88.7 percent / CH₃ONa / methanol / Ambient temperature; overnight

4: 84 percent / pyridinium chlorochromate / CH₂Cl₂ / Heating; molecular sieves 3A, overnight

5: pyridine

With pyridine; hydrogen; sodium methylate; silver fluoride; pyridinium chlorochromate; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; cyclohexane;
DOI:10.1246/bcsj.57.2538

Reference yield:

: 62346-15-0
methyl 2,6-dideoxy-β-L-lyxo-hexopyranoside

: 93978-88-2
Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / pyridine / Ambient temperature; overnight

2: 62.2 percent / CF₃CO₂H / CH₂Cl₂; cyclohexane / 72 h / Ambient temperature

3: 88.7 percent / CH₃ONa / methanol / Ambient temperature; overnight

4: 84 percent / pyridinium chlorochromate / CH₂Cl₂ / Heating; molecular sieves 3A, overnight

5: pyridine

With pyridine; sodium methylate; pyridinium chlorochromate; trifluoroacetic acid; In methanol; dichloromethane; cyclohexane;
DOI:10.1246/bcsj.57.2538

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 93978-88-2
Methanesulfonic acid (2S,3R,4R,6S)-3-benzyloxy-4-cyano-6-methoxy-2-methyl-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 62.2 percent / CF₃CO₂H / CH₂Cl₂; cyclohexane / 72 h / Ambient temperature

2: 88.7 percent / CH₃ONa / methanol / Ambient temperature; overnight

3: 84 percent / pyridinium chlorochromate / CH₂Cl₂ / Heating; molecular sieves 3A, overnight

4: pyridine

With pyridine; sodium methylate; pyridinium chlorochromate; trifluoroacetic acid; In methanol; dichloromethane; cyclohexane;
DOI:10.1246/bcsj.57.2538