3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide]

Base Information

• Chemical Name: 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide]
• CAS No.: 1449137-78-3
• Molecular Formula: C₂₄H₂₈N₄O₄
• Molecular Weight: 436.511
• Mol file: 1449137-78-3.mol

Synonyms:3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide]

Chemical Property of 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide]

There total 6 articles about 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

6-(2,2,2-trichloroacetyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide (1449136-92-8) + C-(3,5-dimethylisoxazol-4-yl)methylamine (131052-47-6) → 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide] (1449137-78-3)

Guidance literature:

In tetrahydrofuran; at 25 ℃; Reflux;

Reference yield:

1-phenylpropylamine (2941-20-0,3082-64-2,3789-59-1,35600-74-9) → 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide] (1449137-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 50 °C

1.2: 25 °C

2.1: dichloromethane / 20 - 40 °C

3.1: tetrahydrofuran / 25 °C / Reflux

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ethyl ester (1449136-33-7) → 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide] (1449137-78-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 4 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 50 °C

2.2: 25 °C

3.1: dichloromethane / 20 - 40 °C

4.1: tetrahydrofuran / 25 °C / Reflux

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

1-phenylpropylamine

6-(2,2,2-trichloroacetyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide

C-(3,5-dimethylisoxazol-4-yl)methylamine

3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide

Refernces