N-(TERT-BUTOXYCARBONYL)-2-CYCLOHEXYL TRYPTOPHAN ETHYL ESTER

Base Information

• Chemical Name: N-(TERT-BUTOXYCARBONYL)-2-CYCLOHEXYL TRYPTOPHAN ETHYL ESTER
• CAS No.: 115692-42-7
• Molecular Formula: C24H34 N2 O4
• Molecular Weight: 414.53776
• Hs Code.: 2933990090
• Mol file: 115692-42-7.mol

Synonyms:DL-Tryptophan,2-cyclohexyl-N-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester

Chemical Property of N-(TERT-BUTOXYCARBONYL)-2-CYCLOHEXYL TRYPTOPHAN ETHYL ESTER

Chemical Property:

• Refractive Index: 1.561
• PSA: 83.91000
• LogP: 5.41890

Purity/Quality:

99% ^*data from raw suppliers

N-(TERT-BUTOXYCARBONYL)-2-CYCLOHEXYL TRYPTOPHAN ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(TERT-BUTOXYCARBONYL)-2-CYCLOHEXYL TRYPTOPHAN ETHYL ESTER

There total 5 articles about N-(TERT-BUTOXYCARBONYL)-2-CYCLOHEXYL TRYPTOPHAN ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyclohexyl-1H-indole (13141-48-5) → 2-tert-Butoxycarbonylamino-3-(2-cyclohexyl-1H-indol-3-yl)-propionic acid ethyl ester (115692-42-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / Na₂CO₃ / CH₂Cl₂ / 16 h / Ambient temperature

2: 1.) Zn, 2.) 1 N aq. HCl / 1.) AcOH, room temp., overnight

3: Et₃N / 2-methyl-propan-2-ol; H₂O

With hydrogenchloride; sodium carbonate; triethylamine; zinc; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1055/s-1988-27471

Reference yield:

ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate (127033-04-9) → 2-tert-Butoxycarbonylamino-3-(2-cyclohexyl-1H-indol-3-yl)-propionic acid ethyl ester (115692-42-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / Na₂CO₃ / CH₂Cl₂ / 16 h / Ambient temperature

2: 1.) Zn, 2.) 1 N aq. HCl / 1.) AcOH, room temp., overnight

3: Et₃N / 2-methyl-propan-2-ol; H₂O

With hydrogenchloride; sodium carbonate; triethylamine; zinc; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1055/s-1988-27471

Reference yield:

o-(cyclohexylcarboxamido)benzyltriphenylphosphonium chloride (115692-55-2) → 2-tert-Butoxycarbonylamino-3-(2-cyclohexyl-1H-indol-3-yl)-propionic acid ethyl ester (115692-42-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 38 percent / t-BuOK / toluene / 0.5 h / Heating

2: 99 percent / Na₂CO₃ / CH₂Cl₂ / 16 h / Ambient temperature

3: 1.) Zn, 2.) 1 N aq. HCl / 1.) AcOH, room temp., overnight

4: Et₃N / 2-methyl-propan-2-ol; H₂O

With hydrogenchloride; potassium tert-butylate; sodium carbonate; triethylamine; zinc; In dichloromethane; water; toluene; tert-butyl alcohol;

DOI:10.1055/s-1988-27471

upstream raw materials:

di-tert-butyl dicarbonate

2-Amino-3-(2-cyclohexyl-1H-indol-3-yl)-propionic acid ethyl ester; hydrochloride

2-cyclohexyl-1H-indole

ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate

Downstream raw materials:

2-tert-Butoxycarbonylamino-3-(2-cyclohexyl-1H-indol-3-yl)-propionic acid

Refernces