2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole
• CAS No.: 84143-64-6
• Molecular Formula: C₁₆H₂₁N₃O₃S
• Molecular Weight: 335.427

Synonyms:2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole

Chemical Property of 2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole

Chemical Property:

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Technology Process of 2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole

There total 2 articles about 2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C15H20N3O3S2(1-)*K(1+) + methyl iodide (74-88-4) → 2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole (84143-64-6)

Guidance literature:

In ethanol; for 0.0833333h; Heating;

DOI:10.1021/ja00342a044

Reference yield:

(S)-tert-butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate (30189-48-1) → 2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole (84143-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / ethanol

2: 95 percent / aq. ethanol / 0.08 h / Heating

With potassium hydroxide; In ethanol;

DOI:10.1021/ja00342a044

Reference yield: 61.0%

2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-(methylthio)-1,3,4-oxadiazole (84143-64-6) → [(S)-1-(5-Methanesulfonyl-[1,3,4]oxadiazol-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester (84143-73-7)

Guidance literature:

With potassium permanganate; acetic acid; at 25 ℃; for 2h;

DOI:10.1021/ja00342a044

upstream raw materials:

methyl iodide

(S)-tert-butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate

Downstream raw materials:

[(S)-1-(5-Methanesulfonyl-[1,3,4]oxadiazol-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

(S)-N-Boc-phenylalanine benzylamide

2-<1-(S)-(tert-butoxycarbonylamino)phenethyl>-5-azido-1,3,4-oxadiazole

2-(1-(S)-aminophenethyl)-5-azido-1,3,4-oxadiazole

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