N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide

Base Information

• Chemical Name: N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide
• CAS No.: 366456-41-9
• Molecular Formula: C₂₂H₂₀N₂O₂
• Molecular Weight: 344.413
• Mol file: 366456-41-9.mol

Synonyms:N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide

Chemical Property of N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide

There total 3 articles about N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(2-benzoyl-4-nitrophenyl)-2-(3-methylphenyl)acetamide (366456-12-4) → N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide (366456-41-9)

Guidance literature:

With tin(ll) chloride; In ethyl acetate; for 2h; Heating;

DOI:10.1021/jm010872r

Reference yield:

2-amino-5-nitrobenzophenone (1775-95-7) → N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide (366456-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; dioxane / 2 h / Heating

2: SnCl₂*2H₂O / ethyl acetate / 2 h / Heating

With tin(ll) chloride; In 1,4-dioxane; ethyl acetate; toluene;

DOI:10.1016/S0960-894X(02)01003-X

Reference yield:

2-(3-methylphenyl)acetyl chloride (13910-79-7) → N-(4-amino-2-benzoylphenyl)-3-methylphenylacetic acid amide (366456-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; dioxane / 2 h / Heating

2: SnCl₂*2H₂O / ethyl acetate / 2 h / Heating

With tin(ll) chloride; In 1,4-dioxane; ethyl acetate; toluene;

DOI:10.1016/S0960-894X(02)01003-X

upstream raw materials:

N-(2-benzoyl-4-nitrophenyl)-2-(3-methylphenyl)acetamide

2-amino-5-nitrobenzophenone

2-(3-methylphenyl)acetyl chloride

Downstream raw materials:

N-[3-benzoyl-4-[2-(3-methylphenyl)acetylamino]phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide