{9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium

Base Information

• Chemical Name: {9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium
• CAS No.: 287401-72-3
• Molecular Formula: C₃₅H₄₅N₄O₄
• Molecular Weight: 585.767
• Mol file: 287401-72-3.mol

Synonyms:{9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium

Chemical Property of {9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium

There total 1 articles about {9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-BOC-1,2-diaminoethane (57260-73-8) + rhodamine B (81-88-9) → {9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium (287401-72-3)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 10h;

DOI:10.1021/jo991836r

Reference yield: 95.0%

{9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium (287401-72-3) → {9-[2-(2-amino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium (287401-73-4)

Guidance literature:

{9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium; In trifluoroacetic acid; at 20 ℃; for 3h;

With Dowex 66; In methanol; pH=7.0; Further stages.;

DOI:10.1021/jo991836r

Reference yield:

{9-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium (287401-72-3) → [9-(2-{2-[21-(2-{2-[2-(bis-carboxymethyl-amino)-ethoxy]-ethoxy}-ethylcarbamoyl)-heneicosa-10,12-diynoylamino]-ethylcarbamoyl}-phenyl)-6-diethylamino-xanthen-3-ylidene]-diethyl-ammonium

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 3 h / 20 °C

1.2: 95 percent / Dowex 66 / methanol / pH 7.0

2.1: 80 percent / Et₃N; BOP / CHCl₃ / 20 h / 20 °C

3.1: 79 percent / LiOH / tetrahydrofuran; methanol / 12 h / 20 °C

With lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; chloroform; trifluoroacetic acid; 1.1: Elimination / 1.2: ion exchange / 2.1: Condensation / 3.1: Elimination;

DOI:10.1021/jo991836r

upstream raw materials:

N-BOC-1,2-diaminoethane

rhodamine B

Downstream raw materials:

{9-[2-(2-amino-ethylcarbamoyl)-phenyl]-6-diethylamino-xanthen-3-ylidene}-diethyl-ammonium

[9-(2-{2-[21-(2-{2-[2-(bis-ethoxycarbonylmethyl-amino)-ethoxy]-ethoxy}-ethylcarbamoyl)-heneicosa-10,12-diynoylamino]-ethylcarbamoyl}-phenyl)-6-diethylamino-xanthen-3-ylidene]-diethyl-ammonium

Refernces