5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid

Base Information

• Chemical Name: 5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid
• CAS No.: 1345962-39-1
• Molecular Formula: C₁₈H₂₀N₂O₅
• Molecular Weight: 344.367
• Mol file: 1345962-39-1.mol

Synonyms:5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid

Chemical Property of 5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid

There total 8 articles about 5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.6%

3-(benzyl((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl)amino)propanoic acid (1345962-38-0) → 5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid (1345962-39-1)

Guidance literature:

With Oxone; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid (1345962-37-9) → 5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid (1345962-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / water; tetrahydrofuran

2: Oxone / N,N-dimethyl-formamide; acetonitrile

With manganese(IV) oxide; Oxone; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol (1136-52-3) → 5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid (1345962-39-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dipyridinium dichromate / dichloromethane

2.1: acetic acid / dichloromethane / 0.5 h

2.2: 4 h

3.1: ethanol / 20 °C

4.1: formic acid / water / 3 h / Reflux

4.2: 3 h / 20 °C

5.1: manganese(IV) oxide / water; tetrahydrofuran

6.1: Oxone / N,N-dimethyl-formamide; acetonitrile

With manganese(IV) oxide; Oxone; dipyridinium dichromate; formic acid; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

5-hydroxy-6-methyl-3,4-pyridinedimethanol

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carboxaldehyde

N-benzyl-1-(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanamine