3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid

Base Information

• Chemical Name: 3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid
• CAS No.: 1345962-37-9
• Molecular Formula: C₁₈H₂₂N₂O₄
• Molecular Weight: 330.384
• Mol file: 1345962-37-9.mol

Synonyms:3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid

Chemical Property of 3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid

There total 6 articles about 3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.9%

ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate (1345962-36-8) → 3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid (1345962-37-9)

Guidance literature:

ethyl 3-(benzyl((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)amino)propanoate; With formic acid; In water; for 3h; Reflux;

With water; potassium hydroxide; In methanol; at 20 ℃; for 3h;

Reference yield:

C20H26N2O4 → 3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid (1345962-37-9)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2013.01.073

Reference yield:

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol (1136-52-3) → 3-(benzyl((5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl)amino)propanoic acid (1345962-37-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dipyridinium dichromate / dichloromethane

2.1: acetic acid / dichloromethane / 0.5 h

2.2: 4 h

3.1: ethanol / 20 °C

4.1: formic acid / water / 3 h / Reflux

4.2: 3 h / 20 °C

With dipyridinium dichromate; formic acid; acetic acid; In ethanol; dichloromethane; water;

upstream raw materials:

5-hydroxy-6-methyl-3,4-pyridinedimethanol

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carboxaldehyde

N-benzyl-1-(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanamine

Downstream raw materials:

3-(benzyl((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl)amino)propanoic acid

5-((benzyl(2-carboxyethyl)amino)methyl)-3-hydroxy-2-methylisonicotinic acid