benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester
CAS No.:434956-90-8
Molecular Formula:C₁₆H₂₂O₄
Molecular Weight:278.348
Hs Code.:

Synonyms:benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester

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Chemical Property of benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester

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Technology Process of benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester

There total 7 articles about benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 434956-23-7
benzoic acid (1S,2S)-4-hydroxy-4-methyl-1-(2-methyl-oxiranyl)-pentyl ester

: 434956-72-6
benzoic acid (2S,2'R)-2-(5',5'-dimethyl-tetrahydrofuran-2'-yl)-2-hydroxy-propyl ester

: 434956-90-8
benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester

: 434956-84-0
benzoic acid (1S,1'R)-1-(1',2'-dihydroxy-1'-methyl-ethyl)-4-hydroxy-4-methyl-pentyl ester

: 434956-88-4
benzoic acid (2R,3S)-2,3,6-trihydroxy-2,6-dimethyl-heptyl ester

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; at -40 - 20 ℃; for 12h;
DOI:10.1055/s-2002-19792

Reference yield:

: 98-88-4
benzoyl chloride

: 434956-90-8
benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 95 percent / tetrahydrofuran; hexane / 2 h / 0 °C

2.1: MCPBA / CH₂Cl₂ / 0 °C

3.1: 23 percent / CSA / CH₂Cl₂ / 12 h / -40 - 20 °C

With n-butyllithium; camphor-10-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2002-19792

Reference yield:

: 368887-94-9
benzoic acid (1S)-1-(3-hydroxy-3-methyl-butyl)-2-methyl-allyl ester

: 434956-90-8
benzoic acid (2S,3S)-2-hydroxymethyl-2,6,6-trimethyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: MCPBA / CH₂Cl₂ / 0 °C

2: 23 percent / CSA / CH₂Cl₂ / 12 h / -40 - 20 °C

With camphor-10-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1055/s-2002-19792