(S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate
CAS No.:1338780-20-3
Molecular Formula:C₁₈H₂₄F₂N₄O₃
Molecular Weight:382.41
Hs Code.:

Synonyms:(S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate

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Chemical Property of (S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate

Chemical Property:

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Technology Process of (S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate

There total 4 articles about (S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1338780-19-0
(R)-tert-butyl (1-(2-((2,5-difluorophenyl)(imino)methyl)hydrazinyl)-3-methoxy-3-methyl-1-oxobutan-2-yl)carbamate

: 1338780-20-3
(S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate

Guidance literature:: In xylenes; at 160 ℃;

Reference yield:

: 64248-64-2
2,5-difluorobenzonitrile

: 1338780-20-3
(S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / ethanol / 0.5 h / 20 °C

2: tetrahydrofuran / -5 - 20 °C

3: xylenes / 160 °C

With hydrazine; In tetrahydrofuran; ethanol; xylenes;

Reference yield:

: 288159-40-0,105504-72-1
(R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

: 1338780-20-3
(S)-tert-butyl (1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxy-2-methylpropyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / -5 - 0 °C

3.1: tetrahydrofuran / -5 - 20 °C

4.1: xylenes / 160 °C

With sodium hydride; triethylamine; In tetrahydrofuran; mineral oil; xylenes;