(R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

Base Information

Chemical Name:(R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid
CAS No.:288159-40-0
Molecular Formula:C10H19 N O5
Molecular Weight:233.265
Hs Code.:29225090
European Community (EC) Number:689-946-9
DSSTox Substance ID:DTXSID10461643
Nikkaji Number:J1.849.852I
Wikidata:Q82286020
Mol file:288159-40-0.mol

Synonyms:288159-40-0;(R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid;N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID;Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid;(2R)-3-hydroxy-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic Acid;(R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-methylbutanoic acid;D-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-;(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxy-3-methylbutanoic acid;MFCD02682576;(R)-2-(Boc-amino)-3-hydroxy-3-methylbutanoic acid;SCHEMBL873398;DTXSID10461643;SZVRVSZFEDIMFM-LURJTMIESA-N;AKOS016843610;DS-4595;Boc-(R)-2-amino-3-methylbutanoic acid;N-(tert-Butoxycarbonyl)-3-hydroxy-D-valine;CS-0109503;EN300-7259072;(R)-N-Boc-2-amino-3-hydroxy-3-methylbutanoic acid;N-Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid (Boc-beta,beta-diMe-D-Ser-OH)

Suppliers and Price of (R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
3-Hydroxy-D-valine, N-Boc protected
1 g
$ 576.00

Medical Isotopes, Inc.
N-Boc-(R)-2-amino-3-hydroxy-3-methylbutanoicacid
5 g
$ 1760.00

Matrix Scientific
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
100mg
$ 179.00

Matrix Scientific
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
500mg
$ 651.00

Iris Biotech GmbH
Boc-beta,beta-diMe-D-Ser-OH
25 g
$ 4185.00

Iris Biotech GmbH
Boc-beta,beta-diMe-D-Ser-OH
5 g
$ 1856.25

Crysdot
(R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoicacid 95+%
1g
$ 289.00

Chem-Impex
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoicacid,98%(Chiralpurity) 98%(Chiralpurity)
100MG
$ 106.40

Chem-Impex
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoicacid,≥98%(Chiralpurity) ≥98%(Chiralpurity)
250MG
$ 188.12

Chem-Impex
Boc-(R)-2-amino-3-hydroxy-3-methylbutanoicacid,≥98%(Chiralpurity) ≥98%(Chiralpurity)
5G
$ 1372.13

Total 26 raw suppliers

Chemical Property of (R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

Chemical Property:

Boiling Point:391.1±37.0 °C(Predicted)
PKA:3.62±0.10(Predicted)
PSA：95.86000
Density:1.175±0.06 g/cm3(Predicted)
LogP:1.12610
Storage Temp.:2-8°C
XLogP3:0.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:233.12632271
Heavy Atom Count:16
Complexity:279

Purity/Quality:

99%, ^*data from raw suppliers

3-Hydroxy-D-valine, N-Boc protected ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(C(=O)O)C(C)(C)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](C(=O)O)C(C)(C)O

Technology Process of (R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

There total 3 articles about (R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 182958-73-2
(2R)-2-(N-tert-Butoxycarbonyl)amino-3-hydroxy-3-methylbutanoic acid

: 288159-40-0,105504-72-1
(R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; In phosphate buffer; acetonitrile; at 35 ℃;
DOI:10.1021/jo026260b

Reference yield:

: 95715-85-8
2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester

: 288159-40-0,105504-72-1
(R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether / -78 - 20 °C

2.1: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl; hypochloric acid / acetonitrile; aq. phosphate buffer / 3 h / 35 °C

2.2: 3 h / 35 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; hypochloric acid; In aq. phosphate buffer; diethyl ether; acetonitrile;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 288159-40-0,105504-72-1
(R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 12 h / 20 °C / Cooling with ice

2.1: diethyl ether / -78 - 20 °C

3.1: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl; hypochloric acid / acetonitrile; aq. phosphate buffer / 3 h / 35 °C

3.2: 3 h / 35 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; hypochloric acid; triethylamine; In methanol; aq. phosphate buffer; diethyl ether; acetonitrile;