4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide
• CAS No.: 1394371-75-5
• Molecular Formula: C₂₀H₁₈ClNO₃S₂
• Molecular Weight: 419.953
• Mol file: 1394371-75-5.mol

Synonyms:4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide

Chemical Property of 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide

Chemical Property:

• Boiling Point: 575.2±60.0 °C(Predicted)
• Density: 1.334±0.06 g/cm3(Predicted)

Purity/Quality:

99.90% ^*data from raw suppliers

nAChRagonist1(DUN71755) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide

There total 9 articles about 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

5-(4-chlorophenyl)-3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide (1394373-64-8) + ethylmagnesium bromide (925-90-6) → 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide (1394371-75-5)

Guidance literature:

In tetrahydrofuran; at 25 - 75 ℃;

Reference yield:

methyl 3-bromo-5-(4-chlorophenyl)-4-methylthiophene-2-carboxylate (1394373-04-6) → 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide (1394371-75-5)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 25 - 100 °C / Inert atmosphere

2: sodium hydroxide; ethanol / 25 - 55 °C

3: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 25 °C / Inert atmosphere

4: triethylamine / dichloromethane / 2 h / 25 °C

5: tetrahydrofuran / 25 - 75 °C

With oxalyl dichloride; ethanol; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; 1: Suzuki Coupling;

Reference yield:

methyl-5-(4-chlorophenyl)-4-methylthiophene-2-carboxylate (1394375-53-1) → 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide (1394371-75-5)

Guidance literature:

Multi-step reaction with 6 steps

1: bromine; zinc(II) chloride / chloroform / 25 - 65 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 25 - 100 °C / Inert atmosphere

3: sodium hydroxide; ethanol / 25 - 55 °C

4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 25 °C / Inert atmosphere

5: triethylamine / dichloromethane / 2 h / 25 °C

6: tetrahydrofuran / 25 - 75 °C

With oxalyl dichloride; ethanol; bromine; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; chloroform; toluene; 2: Suzuki Coupling;

upstream raw materials:

5-(4-chlorophenyl)-3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

ethylmagnesium bromide

ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid

Downstream raw materials:

4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide

4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N-methylbenzenesulfonamide