4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide

Base Information

Chemical Name:4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide
CAS No.:1394372-52-1
Molecular Formula:C₂₂H₂₂ClNO₃S₂
Molecular Weight:448.007
Hs Code.:

Synonyms:4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide

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Chemical Property of 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide

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Technology Process of 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide

There total 7 articles about 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.38%

: 1394371-75-5
4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide

: 74-88-4
methyl iodide

: 1394372-52-1
4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide

: 1394372-54-3
4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N-methylbenzenesulfonamide

Guidance literature:: 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide; With potassium carbonate; In acetonitrile; at 25 ℃; for 0.25h;

methyl iodide; In acetonitrile; at 25 ℃; for 15h;

Reference yield:

: 1394373-04-6
methyl 3-bromo-5-(4-chlorophenyl)-4-methylthiophene-2-carboxylate

: 1394372-52-1
4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide

: 1394372-54-3
4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 25 - 100 °C / Inert atmosphere

2.1: sodium hydroxide; ethanol / 25 - 55 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 2 h / 25 °C

5.1: tetrahydrofuran / 25 - 75 °C

6.1: potassium carbonate / acetonitrile / 0.25 h / 25 °C

6.2: 15 h / 25 °C

With oxalyl dichloride; ethanol; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; 1.1: Suzuki Coupling;

Reference yield:

: 1394375-53-1
methyl-5-(4-chlorophenyl)-4-methylthiophene-2-carboxylate

: 1394372-52-1
4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N,N-dimethylbenzenesulfonamide

: 1394372-54-3
4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine; zinc(II) chloride / chloroform / 25 - 65 °C / Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 25 - 100 °C / Inert atmosphere

3.1: sodium hydroxide; ethanol / 25 - 55 °C

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 25 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 25 °C

6.1: tetrahydrofuran / 25 - 75 °C

7.1: potassium carbonate / acetonitrile / 0.25 h / 25 °C

7.2: 15 h / 25 °C

With oxalyl dichloride; ethanol; bromine; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; chloroform; toluene; acetonitrile; 2.1: Suzuki Coupling;