2-(4-bromophenoxy)-1,3-dihydroxypropane

Base Information

• Chemical Name: 2-(4-bromophenoxy)-1,3-dihydroxypropane
• CAS No.: 1228117-35-8
• Molecular Formula: C₉H₁₁BrO₃
• Molecular Weight: 247.089
• Mol file: 1228117-35-8.mol

Synonyms:2-(4-bromophenoxy)-1,3-dihydroxypropane

Chemical Property of 2-(4-bromophenoxy)-1,3-dihydroxypropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-bromophenoxy)-1,3-dihydroxypropane

There total 3 articles about 2-(4-bromophenoxy)-1,3-dihydroxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(4-bromophenoxy)malonic acid dimethyl ester (1228117-34-7) → 2-(4-bromophenoxy)-1,3-dihydroxypropane (1228117-35-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 - 75 ℃; Inert atmosphere;

DOI:10.1021/jm100181s

Reference yield: 64.0%

2-(4-bromophenoxy)-1,3-diacetoxypropane (1369534-94-0) → 2-(4-bromophenoxy)-1,3-dihydroxypropane (1228117-35-8)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 28h; Inert atmosphere;

DOI:10.1021/jm300101n

Reference yield:

4-bromo-phenol (106-41-2) → 2-(4-bromophenoxy)-1,3-dihydroxypropane (1228117-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene / 5.5 h / 20 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran; methanol / 28 h / 20 °C / Inert atmosphere

With water; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/jm300101n

upstream raw materials:

2-(4-bromophenoxy)malonic acid dimethyl ester

2-(4-bromophenoxy)-1,3-diacetoxypropane

4-bromo-phenol

Downstream raw materials:

5-(4-bromophenoxy)-2,2-dimethyl-[1,3]dioxane

2-(4-bromophenoxy)-3-tosyloxy-1-propanol