3,6-dibromochromone

Base Information

• Chemical Name: 3,6-dibromochromone
• CAS No.: 115237-39-3
• Molecular Formula: C9H4 Br2 O2
• Molecular Weight: 303.938
• Hs Code.: 2932990090
• Mol file: 115237-39-3.mol

Synonyms:3,6-Dibromo-4H-chromen-4-one;3,6-dibromo-4H-1-benzopyran-4-one;

Chemical Property of 3,6-dibromochromone

Chemical Property:

• PSA: 30.21000
• LogP: 3.31800

Purity/Quality:

99% ^*data from raw suppliers

3,6-Dibromo-4H-chromen-4-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-dibromochromone

There total 4 articles about 3,6-dibromochromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C11H12BrNO2 (115237-38-2) → 3,6-dibromo-4H-1-benzopyran-4-one (115237-39-3)

Guidance literature:

With [bis(acetoxy)iodo]benzene; potassium bromide; at 20 ℃; for 12h;

DOI:10.1039/d0nj00825g

Reference yield:

4-bromo-phenol (106-41-2) → 3,6-dibromo-4H-1-benzopyran-4-one (115237-39-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / pyridine / 2 h / 100 °C

2: 62 percent / aluminium trichloride / 3 h / 150 °C

3: 2.) bromine / 1.) 100 deg C, 2 h; 2.) chloroform, 5 min, 0 deg C

With aluminium trichloride; bromine; In pyridine;

DOI:10.1039/P19870002597

Reference yield:

4-bromophenyl acetate (1927-95-3) → 3,6-dibromo-4H-1-benzopyran-4-one (115237-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / aluminium trichloride / 3 h / 150 °C

2: 2.) bromine / 1.) 100 deg C, 2 h; 2.) chloroform, 5 min, 0 deg C

With aluminium trichloride; bromine;

DOI:10.1039/P19870002597

upstream raw materials:

5-Bromo-2-hydroxyacetophenone

N,N-dimethyl-formamide dimethyl acetal

4-bromo-phenol

4-bromophenyl acetate

Downstream raw materials:

2-(5-bromo-2-hydroxybenzoyl)-4H-furo[3,2-c]chromen-4-one

(E,E)-dimethyl 3,3'-(4-oxo-4H-1-benzopyran-3,6-diyl)bispropenoate

methyl 3-<2-hydroxy-5-<(E)-2-methoxycarbonyl-ethanyl>benzoyl>benzoate

Refernces

• 1、 Lin, Yan,Liu, Yunyun,Wan, Jie-Ping. "Synthesis of 3-halochromones with simple KX halogen sources enabled by: In situ halide oxidation". . p. 8120 - 8124. Retrieved 2020/06/09.