Technology Process of (2S,4S,7R)-1-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-7-methyl-octane-2,4-diol
There total 10 articles about (2S,4S,7R)-1-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-7-methyl-octane-2,4-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran;
Ambient temperature;
DOI:10.1016/S0040-4039(00)61612-X
- Guidance literature:
-
Multi-step reaction with 8 steps
1: imidazole / dimethylformamide / 0 °C
2: H2 / 10 percent Pd-C / methanol / Ambient temperature
3: TEA, DCM / 0 °C
4: LiBr, NaHCO3 / tetrahydrofuran / Ambient temperature
5: 60 percent / 1.) LiNH2 / liquid ammonia / -33 °C / 1.) 2 h, 2.) 16 h
6: 95 percent / H2, quinoline / Lindlar's catalyst / methanol
7: (-)-DIPT, TBHP, Ti(O-i-Pr)4, 3 Angstroem molecular sieves, DCM
8: 75 percent / Red-Al / tetrahydrofuran / Ambient temperature
With
1H-imidazole; quinoline; titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium amide; 3 A molecular sieve; TEA; hydrogen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; sodium hydrogencarbonate; D-(-)-diisopropyl tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium bromide;
palladium on activated charcoal; Lindlar's catalyst;
In
tetrahydrofuran; methanol; ammonia; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)61612-X
- Guidance literature:
-
Multi-step reaction with 9 steps
1: NaBH4 / methanol / 0 °C
2: imidazole / dimethylformamide / 0 °C
3: H2 / 10 percent Pd-C / methanol / Ambient temperature
4: TEA, DCM / 0 °C
5: LiBr, NaHCO3 / tetrahydrofuran / Ambient temperature
6: 60 percent / 1.) LiNH2 / liquid ammonia / -33 °C / 1.) 2 h, 2.) 16 h
7: 95 percent / H2, quinoline / Lindlar's catalyst / methanol
8: (-)-DIPT, TBHP, Ti(O-i-Pr)4, 3 Angstroem molecular sieves, DCM
9: 75 percent / Red-Al / tetrahydrofuran / Ambient temperature
With
1H-imidazole; quinoline; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; lithium amide; 3 A molecular sieve; TEA; hydrogen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; sodium hydrogencarbonate; D-(-)-diisopropyl tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium bromide;
palladium on activated charcoal; Lindlar's catalyst;
In
tetrahydrofuran; methanol; ammonia; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)61612-X
![(R)-2-Benzyloxy-1-{(2R,3S)-3-[(R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-butyl]-oxiranyl}-ethanol](/Databaselist/images/loading.webp)
