1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride

Base Information

• Chemical Name: 1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride
• CAS No.: 1283089-04-2
• Molecular Formula: C₂₄H₂₈N₃O₃*Cl
• Molecular Weight: 441.958

Synonyms:1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride

Chemical Property of 1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride

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Technology Process of 1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride

There total 4 articles about 1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(4-methoxybenzyl)-3-(N-methyl-N-phenylamino)-4-(piperidin-1-yl)-1H-pyrrole-2,5-dione (1283089-01-9) → 1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride (1283089-04-2)

Guidance literature:

With aluminum (III) chloride; methoxybenzene; at 20 ℃; for 12h;

DOI:10.1021/jo1025805

Reference yield:

1-(4-methoxybenzyl)-3-(N-methyl-N-phenylamino)-4-bromo-1H-pyrrole-2,5-dione (1283088-78-7) → 1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride (1283089-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

2: aluminum (III) chloride; methoxybenzene / 12 h / 20 °C

With aluminum (III) chloride; methoxybenzene; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jo1025805

Reference yield:

N-methylaniline (100-61-8) → 1-(4-methoxybenzyl)-1-(4-(methyl(phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidinium chloride (1283089-04-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrahydrofuran / 0.5 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

3: aluminum (III) chloride; methoxybenzene / 12 h / 20 °C

With aluminum (III) chloride; sodium carbonate; methoxybenzene; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo1025805

upstream raw materials:

1-(4-methoxybenzyl)-3-(N-methyl-N-phenylamino)-4-bromo-1H-pyrrole-2,5-dione

1-(4-methoxybenzyl)-3-(N-methyl-N-phenylamino)-4-(piperidin-1-yl)-1H-pyrrole-2,5-dione

N-methylaniline

3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione

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