3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione
• CAS No.: 205128-48-9
• Molecular Formula: C₁₂H₉Br₂NO₃
• Molecular Weight: 375.016
• Mol file: 205128-48-9.mol

Synonyms:3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione

Chemical Property of 3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione

There total 1 articles about 3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,3-dibromomaleic anhydride (1122-12-9) + 4-methoxy-benzylamine (2393-23-9) → 3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione (205128-48-9)

Guidance literature:

With ammonium acetate; acetic acid; for 3h; Heating;

DOI:10.1016/j.tet.2005.03.016

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + 3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione (205128-48-9) → 1-(4-methoxybenzyl)-3-bromo-4-morpholino-1H-pyrrole-2,5-dione (1283088-76-5)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1021/jo1025805

Reference yield: 96.0%

4-(dimethylamino)benzene-boronic acid (28611-39-4) + 3,4-dibromo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione (205128-48-9) → 1-(4-methoxybenzyl)-3,4-bis(4-(dimethylamino)phenyl)-1H-pyrrole-2,5-dione (1283088-56-1)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo1025805

upstream raw materials:

2,3-dibromomaleic anhydride

4-methoxy-benzylamine

Downstream raw materials:

3,4-diiodo-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione

3,4-diiodo-2,5-dihydro-1-(4-hydroxybenzyl)-1H-pyrrole-2,5-dione

3,4-bis[5-(diethoxymethyl)fur-2-yl]-2,5-dihydro-1-(4-methoxybenzyl)-1H-pyrrole-2,5-dione

3,4-bis[5-(diethoxymethyl)furan-2-yl]-2,5-dihydro-1-(4-hydroxybenzyl)-1H-pyrrole-2,5-dione