(E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide

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Chemical Name:(E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide
CAS No.:1453190-47-0
Molecular Formula:C₄₂H₄₂N₄O₈
Molecular Weight:730.817
Hs Code.:

Synonyms:(E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide

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Chemical Property of (E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide

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Technology Process of (E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide

There total 7 articles about (E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₆H₄₆N₄O₁₀

: 1453190-47-0
(E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide

Guidance literature:: With methanol; sodium methylate; for 1h; Reflux;
DOI:10.1016/j.tetlet.2013.07.134

Reference yield:

: 1453190-46-9
di-tert-butyl 1,2-bis(2-(5-methoxy-1-tosyl-indol-3-yl)ethyl)hydrazine-1,2-dicarboxylate

: 1453190-47-0
(E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: acetyl chloride; methanol / 18 h / 0 - 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

3: sodium methylate; methanol / 1 h / Reflux

With methanol; sodium methylate; N-ethyl-N,N-diisopropylamine; acetyl chloride; In dichloromethane;
DOI:10.1016/j.tetlet.2013.07.134

Reference yield:

: 1026250-24-7
2-(5-methoxy-1-tosyl-1H-indol-3-yl)ethyl 4-methylbenzenesulfonate

: 1453190-47-0
(E)-3-(4-hydroxy-3-metboxyphenyl)-N'-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)-N,N'-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)acrylohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 120 h / 20 °C / Inert atmosphere

2: acetyl chloride; methanol / 18 h / 0 - 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

4: sodium methylate; methanol / 1 h / Reflux

With methanol; sodium methylate; caesium carbonate; N-ethyl-N,N-diisopropylamine; acetyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2013.07.134