C₁₅H₁₆F₃N₃OS

Base Information

Chemical Name:C₁₅H₁₆F₃N₃OS
CAS No.:1357476-68-6
Molecular Formula:C₁₅H₁₆F₃N₃OS
Molecular Weight:343.373
Hs Code.:

C<sub>15</sub>H<sub>16</sub>F<sub>3</sub>N<sub>3</sub>OS

Synonyms:C₁₅H₁₆F₃N₃OS

Suppliers and Price of C₁₅H₁₆F₃N₃OS

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)acetamide 95%
5g
$ 4218.00

Matrix Scientific
N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)acetamide 95%
1g
$ 1828.00

Total 2 raw suppliers

Chemical Property of C₁₅H₁₆F₃N₃OS

Chemical Property:

Density:1.305±0.06 g/cm3(Predicted)

Purity/Quality:

95%-98% ^*data from raw suppliers

N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)acetamide 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of C₁₅H₁₆F₃N₃OS

There total 6 articles about C₁₅H₁₆F₃N₃OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 7336-51-8
2-acetamido-4-methylthiazole

: 1357476-67-5
4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine

: 1357476-68-6
C₁₅H₁₆F₃N₃OS

Guidance literature:: With palladium diacetate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 120 ℃; for 2h;
DOI:10.1016/j.bmcl.2013.05.007

Reference yield:

: 889940-13-0
3,3,3-trifluoro-2,2-dimethylpropanoic acid

: 1357476-68-6
C₁₅H₁₆F₃N₃OS

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / chloroform / 4 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2.5 h / -78 - 20 °C

2.3: -10 - 20 °C

3.1: ammonia / water / 1 h / 65 °C

4.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 1 h / 85 °C

5.1: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; caesium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C

With oxalyl dichloride; ammonia; palladium diacetate; caesium carbonate; lithium hexamethyldisilazane; tri tert-butylphosphoniumtetrafluoroborate; phosphorus(V) oxybromide; In tetrahydrofuran; chloroform; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.05.007

Reference yield:

: 1163707-53-6
3,3,3-trifluoro-2,2-dimethylpropanoyl chloride

: 1357476-68-6
C₁₅H₁₆F₃N₃OS

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 2.5 h / -78 - 20 °C

1.3: -10 - 20 °C

2.1: ammonia / water / 1 h / 65 °C

3.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 1 h / 85 °C

4.1: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; caesium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C

With ammonia; palladium diacetate; caesium carbonate; lithium hexamethyldisilazane; tri tert-butylphosphoniumtetrafluoroborate; phosphorus(V) oxybromide; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.05.007