6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.:1361960-73-7
Molecular Formula:C₁₈H₁₄F₃N₇
Molecular Weight:385.351
Hs Code.:

Synonyms:6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Chemical Property of 6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Technology Process of 6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 5 articles about 6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 1361961-43-4
1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1361960-73-7
6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: 1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; With sodium methylate; In methanol; at 20 ℃; for 1h;

With potassium iodide; In methanol; at 50 ℃;

With 15-crown-5; sodium methylate; In tetrahydrofuran; at 55 ℃; for 6h;

Reference yield:

: 5346-53-2
5-amino-4-cyano-1-(2-hydroxyethyl)-pyrazole

: 1361960-73-7
6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; tetrachloromethane / dichloromethane / 72 h / 20 °C

2.1: sulfuric acid / 2 h / 20 °C

2.2: 0.08 h / 0 °C

3.1: trimethylsilyl polyphosphate / 130 °C

4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 100 °C

4.2: 1 h / 20 °C

5.1: sodium methylate / methanol / 1 h / 20 °C

5.2: 50 °C

5.3: 6 h / 55 °C

With tetrachloromethane; sulfuric acid; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trichlorophosphate; In methanol; dichloromethane;

Reference yield:

: 89466-60-4
1-(2-chloroethyl)-5-amino-4-cyanopyrazole

: 1361960-73-7
6-(difluro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-1-vinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 2 h / 20 °C

1.2: 0.08 h / 0 °C

2.1: trimethylsilyl polyphosphate / 130 °C

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 100 °C

3.2: 1 h / 20 °C

4.1: sodium methylate / methanol / 1 h / 20 °C

4.2: 50 °C

4.3: 6 h / 55 °C

With sulfuric acid; sodium methylate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol;