1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

Base Information

Chemical Name:1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol
CAS No.:1361961-41-2
Molecular Formula:C₁₄H₁₀ClF₃N₄O
Molecular Weight:342.708
Hs Code.:

Synonyms:1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

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Chemical Property of 1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

Chemical Property:

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Technology Process of 1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

There total 3 articles about 1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361961-40-1
5-amino-1-(2-chloroethyl)-1H-pyrazole-4-carboxamide

: 94010-78-3
2,2-difluoro-2-(4-fluorophenyl)acetic acid

: 1361961-41-2
1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

Guidance literature:: With trimethylsilyl polyphosphate; at 130 ℃;

Reference yield:

: 5346-53-2
5-amino-4-cyano-1-(2-hydroxyethyl)-pyrazole

: 1361961-41-2
1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; tetrachloromethane / dichloromethane / 72 h / 20 °C

2.1: sulfuric acid / 2 h / 20 °C

2.2: 0.08 h / 0 °C

3.1: trimethylsilyl polyphosphate / 130 °C

With tetrachloromethane; sulfuric acid; triphenylphosphine; In dichloromethane;

Reference yield:

: 89466-60-4
1-(2-chloroethyl)-5-amino-4-cyanopyrazole

: 1361961-41-2
1-(2-chloroethyl)-6-(difluro-(4-fluorophenyl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 2 h / 20 °C

1.2: 0.08 h / 0 °C

2.1: trimethylsilyl polyphosphate / 130 °C

With sulfuric acid;