5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

Base Information

Chemical Name:5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one
CAS No.:815620-59-8
Molecular Formula:C₂₁H₃₆O₃Si
Molecular Weight:364.601
Hs Code.:

5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

Synonyms:5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

Suppliers and Price of 5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

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Technology Process of 5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

There total 4 articles about 5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 815620-58-7
5-hydroxy-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

: 815620-59-8
5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1055/s-2004-832813

Reference yield:

: 104-93-8
p-methylanizole

: 815620-59-8
5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / AlCl₃ / 1,2-dichloro-ethane; CH₂Cl₂ / 35 °C

2: 74 percent / NaNH₂ / toluene / 50 °C

3: 83 percent / Cy₂BH / tetrahydrofuran / 0 °C

4: 90 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; aluminium trichloride; bis(cyclohexanyl)borane; sodium amide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 1: Friedel-Crafts acylation;
DOI:10.1055/s-2004-832813

Reference yield:

: 30574-34-6
1-(2-methoxy-5-methyl phenyl)-2-methyl-propane-1-one

: 815620-59-8
5-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-pentan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / NaNH₂ / toluene / 50 °C

2: 83 percent / Cy₂BH / tetrahydrofuran / 0 °C

3: 90 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; bis(cyclohexanyl)borane; sodium amide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2004-832813