4-((4-(DIMETHYLAMINO)PHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE

Base Information

• Chemical Name: 4-((4-(DIMETHYLAMINO)PHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE
• CAS No.: 132603-49-7
• Molecular Formula: C₁₉H₁₉N₃O
• Molecular Weight: 305.379
• Mol file: 132603-49-7.mol

Synonyms:E-1-phenyl-3-methyl-4-<(4-dimethylaminophenyl)methylene>-5-pyrazolone

Chemical Property of 4-((4-(DIMETHYLAMINO)PHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE

Chemical Property:

• Boiling Point: 467.8±55.0 °C(Predicted)
• PKA: 3.59±0.24(Predicted)
• Density: 1.11±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-((4-(dimethylamino)phenyl)methylene)-3-methyl-1-phenyl-2-pyrazolin-5-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-(DIMETHYLAMINO)PHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE

There total 8 articles about 4-((4-(DIMETHYLAMINO)PHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-methyl-2-phenyl-2H-pyrazol-3-ol (942-32-5) + N,N-dimethyl-4-((phenylimino)methyl)aniline (889-37-2,1613-99-6) → E-1-phenyl-3-methyl-4-<(4-dimethylaminophenyl)methylene>-5-pyrazolone (132603-49-7,25111-96-0)

Guidance literature:

In ethanol; Ambient temperature;

DOI:10.1007/BF00816851

Reference yield: 84.0%

4-dimethylamino-benzaldehyde (100-10-7) + edaravone (89-25-8) → E-1-phenyl-3-methyl-4-<(4-dimethylaminophenyl)methylene>-5-pyrazolone (132603-49-7,25111-96-0)

Guidance literature:

With aminosulfonic acid; In ethanol; at 35 ℃; for 2.5h; Sonication; Green chemistry;

DOI:10.1016/j.molstruc.2020.129586

Reference yield: 46.0%

[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-(5-methyl-2-phenyl-2H-pyrazol-3-yl)-amine (102769-77-7) + edaravone (89-25-8) → E-1-phenyl-3-methyl-4-<(4-dimethylaminophenyl)methylene>-5-pyrazolone (132603-49-7,25111-96-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.25h; other reagent: pyridine;

upstream raw materials:

4-dimethylamino-benzaldehyde

edaravone

[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-(5-methyl-2-phenyl-2H-pyrazol-3-yl)-amine

5-methyl-2-phenyl-2H-pyrazol-3-ol