N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide

Base Information

Chemical Name:N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide
CAS No.:1363358-73-9
Molecular Formula:C₂₆H₂₇ClFN₅O₃
Molecular Weight:511.983
Hs Code.:

Synonyms:N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide

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Chemical Property of N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide

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Technology Process of N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide

There total 9 articles about N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1363359-64-1
N-(4-(3-chloro-4-fluorophenyl))-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-4,6-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1363358-73-9
N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1363358-73-9
N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / 2-methoxy-ethanol / Reflux

2.1: nitric acid; sulfuric acid

3.1: thionyl chloride

4.1: isopropyl alcohol

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

5.2: 50 °C / Inert atmosphere

6.1: acetic acid; iron / ethanol / 1 h / 70 °C

7.1: triethylamine / dichloromethane / 0.5 h / 20 °C

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; triethylamine; In ethanol; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 16499-57-3
7-fluoro-3H-quinazolin-4-one

: 1363358-73-9
N-[4-(3-chloro-4-fluorophenylamino)-7-(8-methyl-1-oxa-8-azaspiro[4.5]decan-3-yloxy)quinazolin-6-yl]-acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid; sulfuric acid

2.1: thionyl chloride

3.1: isopropyl alcohol

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

4.2: 50 °C / Inert atmosphere

5.1: acetic acid; iron / ethanol / 1 h / 70 °C

6.1: triethylamine / dichloromethane / 0.5 h / 20 °C

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;