N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide

Base Information

• Chemical Name: N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide
• CAS No.: 1616475-72-9
• Molecular Formula: C₂₄H₂₆N₆O
• Molecular Weight: 414.51

Synonyms:N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide

Chemical Property of N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide

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Technology Process of N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide

There total 10 articles about N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H28N6OS → N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide (1616475-72-9)

Guidance literature:

With potassium carbonate; diisopropyl-carbodiimide; In acetonitrile; at 20 ℃; for 25h; Inert atmosphere;

DOI:10.1016/j.bmcl.2014.05.009

Reference yield:

1-amino-3-(dimethylamino)propane (109-55-7) → N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide (1616475-72-9)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 20 h / Inert atmosphere; Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 19 h / 20 °C / 760.05 Torr / Inert atmosphere

4: acetonitrile / 24 h / 20 °C / Inert atmosphere

5: potassium carbonate; diisopropyl-carbodiimide / acetonitrile / 25 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; diisopropyl-carbodiimide; In 1,4-dioxane; methanol; acetonitrile;

DOI:10.1016/j.bmcl.2014.05.009

Reference yield:

C16H23N5 → N-(1-(3-(dimethylamino)propyl)-6-(pyridin-4-ylamino)-1H-benzo[d]imidazol-2-yl)benzamide (1616475-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 24 h / 20 °C / Inert atmosphere

2: potassium carbonate; diisopropyl-carbodiimide / acetonitrile / 25 h / 20 °C / Inert atmosphere

With potassium carbonate; diisopropyl-carbodiimide; In acetonitrile;

DOI:10.1016/j.bmcl.2014.05.009

upstream raw materials:

1-amino-3-(dimethylamino)propane

N¹-(5-chloro-2-nitrophenyl)-N³,N³-dimethylpropane-1,3-diamine

N³-(3-(dimethylamino)propyl)-4-nitro-N¹-(pyridin-4-yl)benzene-1,3-diamine

2,4-dichloronitrobenzene

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