ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate

Base Information

Chemical Name:ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate
CAS No.:813445-19-1
Molecular Formula:C₁₉H₂₇NO₄
Molecular Weight:333.428
Hs Code.:

Synonyms:ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate

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Chemical Property of ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate

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Technology Process of ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate

There total 4 articles about ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₇NO₄

: 813445-19-1
ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate

Guidance literature:: C₁₉H₂₇NO₄; With sodium tris(acetoxy)borohydride; acetic acid; In acetonitrile; at 0 - 20 ℃;

With sodium hydroxide; In dichloromethane; water; at 0 ℃;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 813445-19-1
ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / Reflux

2: ytterbium(III) triflate / benzene / Reflux

3: sodium tris(acetoxy)borohydride; acetic acid / acetonitrile

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; ytterbium(III) triflate; In tetrahydrofuran; acetonitrile; benzene;
DOI:10.1016/j.bmcl.2011.12.057

Reference yield:

: 14160-65-7,77793-24-9,122090-88-4
ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate

: 813445-19-1
ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ytterbium(III) triflate / benzene / Reflux

2: sodium tris(acetoxy)borohydride; acetic acid / acetonitrile

With sodium tris(acetoxy)borohydride; acetic acid; ytterbium(III) triflate; In acetonitrile; benzene;
DOI:10.1016/j.bmcl.2011.12.057