2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid

Base Information

• Chemical Name: 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid
• CAS No.: 108446-71-5
• Molecular Formula: C₂₅H₁₈N₂O₄
• Molecular Weight: 410.429
• Mol file: 108446-71-5.mol

Synonyms:2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid

Chemical Property of 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid

There total 5 articles about 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

malonic acid (141-82-2) + 3-([1,1’-biphenyl]-4-yl)-1-phenyl-1H-pyrazole-4-carboxaldehyde (108446-64-6) → 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid (108446-71-5)

Guidance literature:

With glycine; In dimethyl sulfoxide; at 20 ℃; for 4h; Green chemistry;

DOI:10.1080/00397911.2016.1164863

Reference yield: 73.8%

malonic acid (141-82-2) + 3-([1,1’-biphenyl]-4-yl)-1-phenyl-1H-pyrazole-4-carboxaldehyde (108446-64-6) → (E)-3-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-acrylic acid (108446-76-0) + 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid (108446-71-5)

Guidance literature:

With piperidine; In pyridine; at 95 - 100 ℃;

Reference yield: 43.9%

2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid diethyl ester (108462-87-9) → 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid (108446-71-5)

Guidance literature:

With sodium hydroxide; In methanol; water; for 2h; Heating;

upstream raw materials:

malonic acid

3-([1,1’-biphenyl]-4-yl)-1-phenyl-1H-pyrazole-4-carboxaldehyde

2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid diethyl ester

1-biphenyl-4-yl-ethanone-phenylhydrazone

Downstream raw materials:

(E)-3-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-acrylic acid