108446-64-6

Usage

Uses

Used in Pharmaceutical Research:
3-BIPHENYL-4-YL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is utilized as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the development of new drugs with potential biological activities, contributing to advancements in medicinal chemistry.
Used in Material Science:
In the field of material science, 3-BIPHENYL-4-YL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE serves as a building block for the creation of novel materials with specific properties. Its incorporation into material compositions can lead to the development of new polymers, coatings, or other materials with tailored characteristics for use in various industries.
Used in Organic Chemistry:
3-BIPHENYL-4-YL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is employed as a reactant or catalyst in various organic chemical reactions. Its presence can facilitate or enhance the synthesis of other complex organic compounds, broadening the scope of organic synthesis and contributing to the discovery of new chemical entities.
Used in Chemical Synthesis:
3-BIPHENYL-4-YL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is used as a starting material in the chemical synthesis of a wide range of compounds. Its versatile structure makes it a valuable component in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals, driving innovation in the chemical industry.

InChI:InChI=1/C22H16N2O/c25-16-20-15-24(21-9-5-2-6-10-21)23-22(20)19-13-11-18(12-14-19)17-7-3-1-4-8-17/h1-16H

Upstream product

• 108446-63-5 1-biphenyl-4-yl-ethanone-phenylhydrazone 
• 68-12-2 N,N-dimethyl-formamide 
• 3724-43-4 Vilsmeier reagent 
• 108446-63-5 1-(1-biphenyl-4-yl-ethylidene)-2-phenylhydrazine 
• 92-91-1 biphenyl-4-acetaldehyde 
• 100-63-0 phenylhydrazine 
• 1373224-00-0 C₄₀H₃₄N₄S 

Downstream Products

• 108462-87-9 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid diethyl ester 
• 372107-04-5 (3-biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-methanol 
• 108446-76-0 (E)-3-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-acrylic acid 
• 475626-39-2 2-{[3-(biphenyl-4-yl)-1-phenyl-1H-pyrazol-4-yl]methylene}-hydrazinecarbothioamide 
• 1357384-09-8 2-{[[3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl]methylene]-hydrazono}-3-(β-D-glucopyranosyl)-4-phenyl-2,3-dihydrothiazole 
• 1357384-10-1 2-{2-[[[3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl]methylene]hydrazono]-4-phenylthiazol-3(2H)-yl}-N'-(4-chlorobenzylidene)acetohydrazide 
• 1357384-11-2 2-{2-[[[3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl]methylene]-hydrazono]-4-phenylthiazol-3(2H)-yl}-N'-(3,4,5-trimethoxybenzylidene)acetohydrazide 
• 1357384-12-3 D-galactose 2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-13-4 D-mannose 2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-14-5 D-xylose 2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-15-6 2,3,4,5,6-penta-O-acetyl-D-galactose-2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]-hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-16-7 2,3,4,5,6-penta-O-acetyl-D-mannose-2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]-hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-17-8 2,3,4,5-tetra-O-acetyl-D-xylose-2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]-hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-03-2 2-{[[3-(biphenyl-4-yl)-1-phenyl-1H-pyrazol-4-yl]methylene]-hydrazono}-4-phenyl-2,3-dihydrothiazole 

Relevant academic research and scientific papers

Temperature-dependent product selectivity in the Vilsmeier-Haack reaction on bis(phenylhydrazones) of bis(aroylmethyl) sulfides (=1,1'-[thiobis(methylene) ]bis[arylmethanone] bis(2-phenylhydrazones)): Synthesis of 3-aroylindoles (=aryl(1H-indol-3-yl)methanones)

The bis(phenylhydrazone) of substituted diphenacyl sulfides (=1,1'-[thiobis(methylene)]bis[arylmethanone] bis(2-phenylhydrazones)) 1 underwent a tandem sequence of reactions upon treatment with Vilsmeier reagent, ultimately yielding 3-aroylindoles (=aryl(1H-indol-3-yl)methanones) 3 (Scheme 1 and Table 1). The reaction seems to be product selective depending upon the reaction temperature. Copyright

Phenyl pyrazole compound, pharmaceutical composition and preparation method and application of phenyl pyrazole compound

The invention discloses a phenyl pyrazole compound, a pharmaceutical composition and a preparation method and application of the phenyl pyrazole compound. The phenyl pyrazole compound shown in a formula I or a formula II can be used for preparing drugs fo

Pyrazole-4-carboxylic Acids from Vanadium-catalyzed Chemical Transformation of Pyrazole-4-carbaldehydes

The conversion of aldehydes into carboxylic acids using oxidizing agents is a common protocol in transformation chemistry. An efficient oxidation strategy of transformation of pyrazole-4-aldehydes to the corresponding acids using vanadium catalysts in the presence of 30% H2O2 as an oxidant is described. The catalytic technology was successfully applied to a range of various 4-formylpyrazoles, and plausible mechanism is also discussed.

Synthesis of pyrrol-2-yl- and pyrazol-4-ylmethylidene derivatives of betulin and allobetulin

Aldol-crotonic condensation of allobetulone and betulonic aldehyde with N-substituted pyrrole-2- and pyrazole-4-carbaldehydes afforded a series of new α,β-unsaturated ketones of lupane series. Their reduction provided 2-ylidene derivatives of allobetulin

Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives

This manuscript describes the synthesis of a new series of porphyrin structures 4a-4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13C NMR, 1H NMR spectroscopy and mass spectral data.

Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives

This manuscript describes the synthesis of a new series of porphyrin structures 4a-4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13C NMR, 1H NMR spectroscopy and mass spectral data.

Synthesis and antimicrobial activity of substituted [(pyrazol-4-yl) methylene]hydrazono-2,3-dihydrothiazoles and their sugar derivatives

A number of new [(pyrazol-4-yl)methylene]hydrazono-2,3-dihydrothiazole derivatives, their sugar hydrazones and N-glycosides were synthesized. Furthermore, N-substituted oxygenated alkyl and hydroxyl derivatives and 1,3,4,-oxadiazoline acyclic nucleoside analogs were prepared. The newly synthesized compounds were tested for their antimicrobial activities and showed moderate to high inhibition activities.

Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity

beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.