PROPOFOL GLUCURONIDE

Base Information

• Chemical Name: PROPOFOL GLUCURONIDE
• CAS No.: 114991-26-3
• Molecular Formula: C₁₈H₂₆O₇
• Molecular Weight: 354.4
• Hs Code.: 29389090
• Mol file: 114991-26-3.mol

Synonyms:Propofolglucuronide

Chemical Property of PROPOFOL GLUCURONIDE

Chemical Property:

• Melting Point: 113-116°C
• PSA: 116.45000
• LogP: 1.20440
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Propofol Glucuronide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Propofol, an anesthetic used in veterinary medicine Propofol β-D-Glucuronide is a metabolite of Propofol (P829750), an anesthetic used in veterinary medicine.

Technology Process of PROPOFOL GLUCURONIDE

There total 3 articles about PROPOFOL GLUCURONIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-diisopropylphenol (2078-54-8) + UDP-glucuronic acid (1245697-26-0,106864-00-0,14520-48-0,30329-32-9,3545-73-1,5918-40-1) → propofol D-glucuronide (114991-26-3)

Guidance literature:

With UDP-glucuronosyltransferase-1A₉; Enzymatic reaction;

DOI:10.1124/dmd.109.029900

Reference yield:

2,6-diisopropylphenol (2078-54-8) + UDP-glucuronic acid (2616-64-0) → propofol D-glucuronide (114991-26-3)

Guidance literature:

With UDP-glucuronosyltransferase 1A₉ from human; magnesium chloride; alamethicin; D-Glucaro-1,4-lacton; In aq. buffer; pH=7.4; Reagent/catalyst;

Reference yield:

2,6-diisopropylphenol (2078-54-8) → Propofol glucuronide (114991-26-3)

Guidance literature:

With recombinant UDP-glucuronosyltransferase 1A₉; In methanol; at 37 ℃; for 0.5h; pH=7.5; Concentration; Reagent/catalyst; Kinetics; Tris-HCl buffer; Enzymatic reaction;

DOI:10.1124/dmd.111.043117

upstream raw materials:

2,6-diisopropylphenol

UDP-glucuronic acid

UDP-glucuronic acid

Refernces

• 1、 Yang, Jing,Zhang, Beibei,Qin, Zi Fei,Zhang, Xiao Jian. "Human UDP-glucuronosyltransferase 1A1, 1A7, 1A8, 1A9 and 1A10 are mainly responsible for icariside II-7-O-glucuronidation". . p. 4960 - 4971. Retrieved 2019/08/12.
• 2、 Wu, Baojian,Wang, Xiaoqiang,Zhang, Shuxing,Hu, Ming. "Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches". experimental part. p. 1544 - 1561. Retrieved 2012/07/27.