Uridine diphosphate glucuronic acid

Base Information

Chemical Name:Uridine diphosphate glucuronic acid
CAS No.:2616-64-0
Molecular Formula:C15H22 N2 O18 P2
Molecular Weight:580.29
Hs Code.:
UNII:04SZC4MEFQ
DSSTox Substance ID:DTXSID00903961
Nikkaji Number:J247.699A
Wikipedia:Uridine_diphosphate_glucuronic_acid
Wikidata:Q277638
Pharos Ligand ID:L4J3N19N3B8J
Metabolomics Workbench ID:37509
ChEMBL ID:CHEMBL228057

Synonyms:Acid, UDP Glucuronic;Acid, Uridine Diphosphoglucuronic;Diphosphoglucuronic Acid, Uridine;Glucuronic Acid, UDP;UDP Glucuronic Acid;UDPGA;Uridine Diphosphate Glucuronic Acid;Uridine Diphosphoglucuronic Acid

Suppliers and Price of Uridine diphosphate glucuronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
UDP-ALPHA-D-GALACTURONIC ACID 95.00%
5MG
$ 504.35

Total 46 raw suppliers

Chemical Property of Uridine diphosphate glucuronic acid

Chemical Property:

Boiling Point:°Cat760mmHg
PKA:1.10±0.50(Predicted)
Flash Point:°C
PSA：333.68000
Density:2.05g/cm³
LogP:-4.70140
XLogP3:-6.4
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:9
Exact Mass:580.03428585
Heavy Atom Count:37
Complexity:1040

Purity/Quality:

99% ^*data from raw suppliers

UDP-ALPHA-D-GALACTURONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Biological Agents -> Nucleic Acids and Derivatives
Canonical SMILES:C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OC3C(C(C(C(O3)C(=O)O)O)O)O)O)O
Isomeric SMILES:C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C(=O)O)O)O)O)O)O
General Description UDP-glucuronic acid (UDP-GlcUA) is a key nucleotide sugar involved in the biosynthesis of glucuronides and polysaccharides, formed through the NAD⁺-dependent oxidation of UDP-glucose by UDP-glucose 6-dehydrogenase (UGDH). The reaction proceeds via covalent thiohemiacetal and thioester intermediates, with Cys²⁷⁶ acting as the catalytic nucleophile, and involves hydride transfer without exchange of the C-5 hydrogen with bulk water. Enzymatic synthesis of UDP-GlcUA is preferred over chemical methods, as demonstrated by gram-scale production using bovine liver UGDH. (2S,3S,4R,5R,6R)-6-[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic is essential for cell-free enzymatic syntheses of oligo- and polysaccharides and plays a role in detoxification pathways via glucuronidation.

Technology Process of Uridine diphosphate glucuronic acid

There total 37 articles about Uridine diphosphate glucuronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 58-98-0
UDP

: 57-50-1
Sucrose

: 2616-64-0
UDP-glucuronic acid

Guidance literature:: With histidine_-6-nicotinamide adenine dinucleotide hydride oxidase; histidine_-6-uridine 5’-diphosphate-α-D-glucose-dehydrogenase; sucrose synthase 1; NAD; In aq. buffer; at 30 ℃; for 5h; pH=7.8; Enzymatic reaction;
DOI:10.1002/adsc.201500180

Reference yield: 89.0%

: 70021-34-0
D-glucuronic acid

: 63-39-8
UTP

: 2616-64-0
UDP-glucuronic acid

Guidance literature:: With glucuronokinase from Arabidopsis thaliana; pyrophosphatase from E_. coli; UDP-sugar pyrophosphorylasegene from Arabidopsis thaliana; ATP; magnesium chloride; In aq. buffer; at 37 ℃; pH=8; Enzymatic reaction;
DOI:10.1016/j.carres.2015.04.001

Reference yield: 87.0%

: 133-89-1
UDP-glucose

: 2616-64-0
UDP-glucuronic acid

Guidance literature:: With Tris buffer; NAD; 2-oxo-propionic acid; for 12h; lactate dehydrogenase, uridine 5'-diphosphoglucose dehydrogenase (UDP-Glc dehydrogenase);
DOI:10.1021/jo00019a026