Tert-butyl 1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:Tert-butyl 1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1207175-15-2
Molecular Formula:C₁₅H₂₂N₂O₂
Molecular Weight:262.352
Hs Code.:
European Community (EC) Number:881-886-3
DSSTox Substance ID:DTXSID80697013

Synonyms:TERT-BUTYL 1-(AMINOMETHYL)-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;1207175-15-2;150417-20-2;tert-butyl 1-(aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate;TERT-BUTYL1-(AMINOMETHYL)-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;tert-butyl 1-(aminomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;SCHEMBL4662999;DTXSID80697013;MFCD11045240;CS-0214922;EN300-205221;F30833;A809042

Suppliers and Price of Tert-butyl 1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl1-(Aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
1g
$ 400.00

Crysdot
tert-Butyl1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 97%
250mg
$ 248.00

Crysdot
tert-Butyl1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 97%
1g
$ 620.00

Chemenu
tert-Butyl1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 97%
1g
$ 580.00

Alichem
tert-Butyl1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
1g
$ 651.00

Total 3 raw suppliers

Chemical Property of Tert-butyl 1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:262.168127949
Heavy Atom Count:19
Complexity:325

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl1-(Aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC2=CC=CC=C2C1CN
Uses tert-Butyl 1-(Aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate is a reagent used in the preparation of praziquantel and analogs used as an antischistosomal drug

Technology Process of Tert-butyl 1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 9 articles about Tert-butyl 1-(aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2-methyl-2-propanyl 1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1207175-15-2
2-methyl-2-propanyl 1-(aminomethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: With hydrazine; In acetonitrile; for 40h; Reflux;

Reference yield: 79.0%

: 1118640-91-7
(±)-tert-butyl 1-cyano-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1207175-15-2
2-methyl-2-propanyl 1-(aminomethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: With hydrogen; In methanol; for 16h;
DOI:10.1016/j.bmcl.2011.11.108

Reference yield:

: 64-04-0
phenethylamine

: 1207175-15-2
2-methyl-2-propanyl 1-(aminomethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / acetonitrile / 24 h / 85 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 20 °C

3: sodium hydrogencarbonate / dichloromethane / 1 h / 20 °C

4: hydrazine / acetonitrile / 24 h / 85 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; hydrazine; trichlorophosphate; In dichloromethane; acetonitrile;