3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine

Base Information

Chemical Name:3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine
CAS No.:1330766-90-9
Molecular Formula:C₂₀H₂₂N₂O
Molecular Weight:306.407
Hs Code.:

Synonyms:3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine

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Chemical Property of 3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine

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Technology Process of 3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine

There total 5 articles about 3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1330766-89-6
2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxy-4,6-dimethylpyridine

: 100-39-0
benzyl bromide

: 1330766-90-9
3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere;

Reference yield: 82.0%

: 1330766-88-5
3-bromo-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine

: 100-39-0
benzyl bromide

: 1330766-90-9
3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine

Guidance literature:: 3-bromo-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; tert-butyl XPhos; In 1,4-dioxane; water; at 100 ℃; for 3h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; mineral oil; at 23 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.07.005

Reference yield:

: 5407-87-4
2-Amino-4,6-dimethylpyridine

: 1330766-90-9
3-(benzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-2,4-dimethylpyridine

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetonitrile / 5 h / 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / toluene / Reflux; Inert atmosphere

3: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

4: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Inert atmosphere

With N-Bromosuccinimide; sodium hydride; toluene-4-sulfonic acid; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile; mineral oil;