C₃₆H₃₄BrN₃O₂

Base Information

• Chemical Name: C₃₆H₃₄BrN₃O₂
• CAS No.: 1384331-19-4
• Molecular Formula: C₃₆H₃₄BrN₃O₂
• Molecular Weight: 620.589
• Mol file: 1384331-19-4.mol

Synonyms:C₃₆H₃₄BrN₃O₂

Chemical Property of C₃₆H₃₄BrN₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₃₄BrN₃O₂

There total 18 articles about C₃₆H₃₄BrN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C35H32BrN3O2 (1384331-18-3) → C36H34BrN3O2 (1384331-19-4)

Guidance literature:

With sodium cyanoborohydride; In water; acetonitrile; at -40 ℃; for 1h;

DOI:10.1016/j.tet.2012.05.071

Reference yield: 36.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C35H32BrN3O2 (1384331-18-3) → C36H34BrN3O2 (1384331-19-4) + C37H36BrN3O3 (1384331-21-8)

Guidance literature:

With sodium cyanoborohydride; In acetonitrile; at 20 ℃;

DOI:10.1016/j.tet.2012.05.071

Reference yield:

9H-fluoren-9-ylmethyl (S)-4-benzyl-5-oxo-1,3-oxazolidine-3-carboxylate (84000-03-3) → C36H34BrN3O2 (1384331-19-4)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylsilane; trifluoroacetic acid / chloroform / 16 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 0 - 20 °C

3: trichlorophosphate / benzene / 1.5 h / Reflux

4: formic acid; triethylamine / N,N-dimethyl-formamide / 13 h

5: sodium cyanoborohydride / water; acetonitrile / 1 h / -40 °C

With triethylsilane; formic acid; sodium cyanoborohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; trichlorophosphate; In dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; benzene; 3: Bischler-Napieralski reaction / 4: Noyori catalytic asymmetric hydrogen-transfer reaction;

DOI:10.1016/j.tet.2012.05.071

upstream raw materials:

formaldehyd

C₃₅H₃₂BrN₃O₂

3-(2-nitrovinyl)-6-bromo-1H-indole

C₃₅H₃₂BrN₃O₃

Downstream raw materials:

eudistomidin H

Refernces