(2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester

Base Information

• Chemical Name: (2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester
• CAS No.: 940055-56-1
• Molecular Formula: C₂₇H₂₄FN₃O₅S
• Molecular Weight: 521.569
• Mol file: 940055-56-1.mol

Synonyms:(2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester

Chemical Property of (2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester

There total 6 articles about (2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(2-{[benzyloxycarbonyl-(2,5-dioxopyrrolidin-3-yl)-amino]-methyl}-5-fluorophenyl)-carbamic acid benzyl ester (940055-55-0) → (2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester (940055-56-1)

Guidance literature:

With tetraphosphorus decasulfide; In tetrahydrofuran; at 90 ℃; for 0.666667h; Microwave irradiation;

Reference yield:

2-amino-4-fluorobenzoic acid cyanomethyl ester (940054-57-9) → (2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester (940055-56-1)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonia / 1,4-dioxane; water / 20 h / 100 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 9 h / Heating / reflux

3: ethyl acetate / 41 h / 20 - 50 °C

4: dmap / tetrahydrofuran / 24 h / 20 °C

5: tetraphosphorus decasulfide / tetrahydrofuran / 0.67 h / 90 °C / Microwave irradiation

With tetraphosphorus decasulfide; dimethylsulfide borane complex; ammonia; dmap; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;

Reference yield:

3-(2-amino-4-fluorobenzylamino)-pyrrolidine-2,5-dione (940054-58-0) → (2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester (940055-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 24 h / 20 °C

2: tetraphosphorus decasulfide / tetrahydrofuran / 0.67 h / 90 °C / Microwave irradiation

With tetraphosphorus decasulfide; dmap; In tetrahydrofuran;

upstream raw materials:

(2-{[benzyloxycarbonyl-(2,5-dioxopyrrolidin-3-yl)-amino]-methyl}-5-fluorophenyl)-carbamic acid benzyl ester

2-aminomethyl-5-fluoro-aniline

2-amino-4-fluorobenzoic acid cyanomethyl ester

3-(2-amino-4-fluorobenzylamino)-pyrrolidine-2,5-dione