2-amino-4-fluorobenzoic acid cyanomethyl ester

Base Information

• Chemical Name: 2-amino-4-fluorobenzoic acid cyanomethyl ester
• CAS No.: 940054-57-9
• Molecular Formula: C₉H₇FN₂O₂
• Molecular Weight: 194.165
• Mol file: 940054-57-9.mol

Synonyms:2-amino-4-fluorobenzoic acid cyanomethyl ester

Chemical Property of 2-amino-4-fluorobenzoic acid cyanomethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-amino-4-fluorobenzoic acid cyanomethyl ester

There total 1 articles about 2-amino-4-fluorobenzoic acid cyanomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-fluoroanthranilic acid (446-32-2) + chloroacetonitrile (107-14-2) → 2-amino-4-fluorobenzoic acid cyanomethyl ester (940054-57-9)

Guidance literature:

With triethylamine; In acetone; at 20 ℃; for 48h;

Reference yield: 88.0%

2-amino-4-fluorobenzoic acid cyanomethyl ester (940054-57-9) → 4-fluoroanthranilamide (119023-25-5)

Guidance literature:

With ammonia; In 1,4-dioxane; water; at 100 ℃; for 20h;

Reference yield:

2-amino-4-fluorobenzoic acid cyanomethyl ester (940054-57-9) → (2-{[benzyloxycarbonyl-(2-oxo-5-thioxopyrrolidin-3-yl)amino]methyl}-5-fluorophenyl)-carbamoyl acid benzyl ester (940055-56-1)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonia / 1,4-dioxane; water / 20 h / 100 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 9 h / Heating / reflux

3: ethyl acetate / 41 h / 20 - 50 °C

4: dmap / tetrahydrofuran / 24 h / 20 °C

5: tetraphosphorus decasulfide / tetrahydrofuran / 0.67 h / 90 °C / Microwave irradiation

With tetraphosphorus decasulfide; dimethylsulfide borane complex; ammonia; dmap; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;

upstream raw materials:

4-fluoroanthranilic acid

chloroacetonitrile

Downstream raw materials:

4-fluoroanthranilamide

2-aminomethyl-5-fluoro-aniline

3-(2-amino-4-fluorobenzylamino)-pyrrolidine-2,5-dione

(2-{[benzyloxycarbonyl-(2,5-dioxopyrrolidin-3-yl)-amino]-methyl}-5-fluorophenyl)-carbamic acid benzyl ester