4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol

Base Information

Chemical Name:4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol
CAS No.:158741-37-8
Molecular Formula:C₂₉H₂₇ClO₃
Molecular Weight:458.985
Hs Code.:

Synonyms:4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol

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Chemical Property of 4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol

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Technology Process of 4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol

There total 6 articles about 4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 144800-99-7
3-(4-hydroxytetrahydro-2H-pyran-4-yl)benzyl bromide

: 156152-32-8
1-phenyl-3-chloromethyl-6-naphthol

: 158741-37-8
4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/jm960301c

Reference yield:

: 132725-90-7
7-methoxy-4-phenyl-2-naphthoic acid

: 158741-37-8
4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / Py*HCl / 10 h / 175 °C

2: 81 percent / SOCl₂ / 18 h / Ambient temperature

3: 65 percent / DIBAL / tetrahydrofuran / 2 h / 0 °C

4: 89 percent / CCl₄, Ph₃P / CH₂Cl₂ / 2 h / Heating

5: 95 percent / Cs₂CO₃ / dimethylformamide / 3 h / Ambient temperature

With tetrachloromethane; thionyl chloride; pyridine hydrochloride; diisobutylaluminium hydride; caesium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960301c

Reference yield:

: 145127-34-0
3-(4-hydroxytetrahydro-2H-pyran-4-yl)toluene

: 158741-37-8
4-[3-(7-Chloromethyl-5-phenyl-naphthalen-2-yloxymethyl)-phenyl]-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / NBS, AIBN / CCl₄ / 1.5 h / Heating

2: 95 percent / Cs₂CO₃ / dimethylformamide / 3 h / Ambient temperature

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); caesium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960301c