7-Methoxy-4-phenylnaphthalene-2-carboxylic acid

Base Information

• Chemical Name: 7-Methoxy-4-phenylnaphthalene-2-carboxylic acid
• CAS No.: 132725-90-7
• Molecular Formula: C18H14O3
• Molecular Weight: 278.307
• ChEMBL ID: CHEMBL1774883
• DSSTox Substance ID: DTXSID40597520
• Wikidata: Q82493082
• Mol file: 132725-90-7.mol

Synonyms:132725-90-7;7-Methoxy-4-phenylnaphthalene-2-carboxylic acid;SCHEMBL9301210;CHEMBL1774883;DTXSID40597520;SEFNGLMUROBBLU-UHFFFAOYSA-N;1-phenyl-3-carboxy-6-methoxynaphthalene

Chemical Property of 7-Methoxy-4-phenylnaphthalene-2-carboxylic acid

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 278.094294304
• Heavy Atom Count: 21
• Complexity: 362

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=CC(=CC(=C2C=C1)C3=CC=CC=C3)C(=O)O

Technology Process of 7-Methoxy-4-phenylnaphthalene-2-carboxylic acid

There total 2 articles about 7-Methoxy-4-phenylnaphthalene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Hydroxy-2-(3-methoxybenzylidene)-4phenylbut-3-enoic acid lactone (84023-85-8) + diethyl ether (60-29-7,927820-24-4) + water (7732-18-5) → 1-naphthalenecarboxylic acid (86-55-5) + 7-methoxy-4-phenyl-2-naphthoic acid (132725-90-7)

Guidance literature:

With hydrogenchloride; In glacial AcOH; hexane;

Reference yield:

→ 7-methoxy-4-phenyl-2-naphthoic acid (132725-90-7)

Guidance literature:

4-Hydroxy-4-phenyl-2-<3-methoxy-benzyliden>-buten-(3)-saeurelacton (IIIm), sd. Eg./konz.HCl (1:1), (3 1/2 h);

DOI:10.1039/jr9610001658

Reference yield: 55.0%

7-methoxy-4-phenyl-2-naphthoic acid (132725-90-7) → 1-phenyl-3-carboxy-6-naphthol (156152-11-3)

Guidance literature:

With pyridine hydrochloride; at 175 ℃; for 10h;

DOI:10.1021/jm960301c

upstream raw materials:

4-Hydroxy-2-(3-methoxybenzylidene)-4phenylbut-3-enoic acid lactone

diethyl ether

water

Downstream raw materials:

1-phenyl-3-carboxy-6-naphthol

1-phenyl-3-ethyl-6-naphthol

1-phenyl-3-acetyl-6-naphthol

1-Phenyl-3-hydroxymethyl-6-naphthol